The 15 Best Drugs for Vessels

*Review of the best according to the editorial board. About the selection criteria. This material is subjective, not an advertisement and does not serve as a guide to purchase. It is necessary to consult with a specialist before purchase.

People often perceive their own health as the sum total of the normal state of the organs. Everybody wants to have a healthy heart, a liver that works well, a clear mind and kidneys that can work efficiently and for many years. But few people think about how to maintain the vascular network in good condition. It carries a huge volume of blood every day. Arterial vessels carry oxygen and plastic substances, and venous vessels carry carbon dioxide and products of tissue metabolism.

The vessels constantly contain not only those substances that the body needs, but also those molecules that have already become unnecessary, and even harmful. In order for the transport of harmful and waste substances through the vascular bed to be safe, it is necessary to keep the inner lining of the vessels, or the endothelium, in good order. If endothelial cells are healthy, they do not carry extra electrical charge, do not attract molecules of harmful substances to themselves, do not change the flow of blood. Healthy endothelial cells allow for many years to avoid the growth of atherosclerotic plaques, thrombotic complications, the risk of chronic vascular failure.

What can happen to blood vessels?

In humans, blood vessels do not always fully perform their function. Firstly, there can be their hereditary damage, blood clotting disorders, congenital and acquired thrombosis, leading to ischemia of organs and tissues. Vessels are prone to dystrophic processes, in which there is incomplete vascular wall, vessels can become inflamed, either by themselves or simultaneously with the process of thrombosis. A good example would be thrombophlebitis, obliterating endarteritis.

Vascular permeability can deteriorate due to the presence of atherosclerotic plaques, there can be dissection of the vessel wall, or their abnormal course. Many of these diseases will require surgery, some will require medication correction, but in many cases over-the-counter medications, which are quite aptly, though not quite correctly, called “vitamins for the blood vessels” will also help.

The modern pharmaceutical industry produces a large variety of vitamin complexes, monocomponent drugs, natural substances that normalize vascular function and exhibit a protective effect. Since there are many such remedies, it is rational to combine them into groups. These are natural vitamins and minerals, agents that eliminate the energy deficit of endothelial and myocardial cells, restore membranes, as well as some agents that have migrated to the preventive sphere from great medicine, but we will talk about them at the end of this material.

This material is an informative review. Drugs, listed in it, are chosen arbitrarily, but still the emphasis is placed on the most effective and popular products, which are easily available in pharmacies of all forms of ownership in Russia. For each medication is given INN, that is, the international nonproprietary name. If there is an original drug first on the market, the name of the original product is listed first in parentheses, followed by some generics, or commercial copies.

Then the price range for the most expensive and high-quality original drug is indicated, and the price of the cheapest drug you can buy in the pharmacy. As a rule, the cheapest drug does not have its commercial name, and is called a generic INN (generic).

The original drug, which is being brought to market for the first time, has the greatest number of different studies, the most money and time has been spent on it, and it costs the most.

The current price range for these drugs for the beginning of 2021 for pharmacies of all forms of ownership in the Russian Federation is given below. The drugs listed below are not ratings, samples, or efficacy studies. This material is not an advertisement, or an invitation to purchase a medicine. All drugs must be prescribed by a doctor with all indications and contraindications taken into account. All data on medications are taken from public sources, solely from the official medication instructions.

Effective vitamins and drugs for blood vessels

Natural Products

Modern pharmacies offer a large number of dietary supplements based on phytoextracts or animal ingredients. Consider the most effective remedies for vascular disease, for the prevention of thrombosis, capillary ischemia.

Taxifolin Baikal (Dihydroquercetin)

Rating: 4.8

Taxifolin Baikal is considered a unique natural compound that is produced from a special part of the Siberian larch wood, which is located at the rump of the tree. The modern industry produces quite a few varieties of dihydroquercetin, but the leader in purity and activity is Baikalsky taxifolin, which is produced by Siberian Kedr. The purity and effectiveness is achieved by the synthesis of a special, crystalline form of ultra-pure dihydroquercetin.

The vitamin is packed in capsules of 300 mg, each capsule contains a powder of white or pale yellow color. Mechanism of action – a powerful antioxidant activity and inhibition of pathological processes of lipid peroxidation, which leads to degeneration and destruction of membranes.

Taxifolin has a pronounced capillary-protective effect. It saves the membranes of the blood capillaries, promotes blood microcirculation, including in the coronary arteries of the heart and brain, prevents the formation of cholesterol plaques and their deposition on the vascular wall, and this, in turn, reduces the risk of heart attacks, strokes and other vascular disasters.

Take taxifolin Baikalsky once a day, one capsule with a meal. The average course of treatment is one month. The price – 1350 rubles for a pack of 30 capsules for a month of treatment.

Advantages and disadvantages

The advantage of Taxifolina baikal (dihydroquercetin) is considered to be very high activity, which is not limited to the protection of capillaries. The preparation has antihistamine action, is an excellent antioxidant, it prevents cell aging, improves liver function and activates tissue respiration. The vitamin is perfectly compliant, it is used once a day, is well tolerated, and significantly increases the body’s immune reserves. Taxifolin prepares him for increased mental and physical exertion.

But this drug has some negative aspects, which are related to the high demand for it and to the peculiarities of its distribution. Taxifolin is a vitamin that doesn’t come cheap. It is only produced by one company, and the quantities are not high enough to make it known to the general medical community and the public. However, it is sold through a network of dealers and is not always available in pharmacies.

Doppelgerz Activ Omega-3

Rating: 4.8

It is a purified polyunsaturated fatty acids derived from the fat of salmon fish. Thus, this remedy is a drug of animal origin. In addition to fatty acids, fat-soluble vitamin E is included. As a result, this complex combats oxidative stress, reduces the amount of fat that circulates in the peripheral blood, and can be deposited on the walls in the form of atherosclerotic plaques.

Means to reduce platelet aggregation, with prolonged use in combination therapy can lower blood pressure, stabilizes cell membranes. Doppelgerz Omega – 3 helps to normalize the immune system, and has a mild anti-inflammatory effect. All these effects together help to reduce the risk of cardiovascular accidents. Still this vitamin for blood vessels is shown to normalize the cerebral circulation: both for prevention and for the treatment of various cerebral vascular diseases (hypertensive encephalopathy).

One capsule contains 800 mg of fish oil and 16 mg of vitamin E. Dosing regimen – one capsule a day with food, the capsule can be washed with water. One pack of 30 capsules for a month of use, on average, costs 400 rubles in pharmacies., It is produced by the German company Kweisser Pharma.

Advantages and disadvantages

A big plus will be the possibility of using it not only for prevention, but also for the treatment of vascular disease. This vitamin can be prescribed for diabetics, just keep in mind that one capsule corresponds to only 0.01 bread units. This vitamin works especially well together with medications to lower cholesterol, and on a hypolipidemic diet. The negative side of the vitamin complex is the inability to cope alone with high cholesterol levels against the background of already existing plaques that impair blood flow, and therefore in such cases it is necessary to connect to therapy cholesterol-lowering drugs, about which there was already a separate article.

Vitamins and minerals

Above were listed herbal remedies, complexes of herbal supplements, monocomponent solutions based on plant extracts, as well as capsules with fish oil. But in the prevention and treatment of cardiovascular disease, minerals and some “real” vitamins are important. Let’s look at the most well-known and commonly used.

Ascorutin

Rating: 4.8

Ascorutin is one of the available and favorite folk vitamins for blood vessels. It consists of ascorbic acid and rutoside, a source of rutin. This vitamin has pronounced vasotropic properties. Its main purpose is to prevent the increased fragility of thin capillaries, reducing their permeability. Strengthened in this way the vascular wall becomes less accessible for the flow of tissue fluid through it, resulting in a decrease in the degree of swelling, especially with varicose veins on the legs. People of age quite often have spontaneous hemorrhages when small vessels rupture, especially in the hands and fingers during exercise. Ascorutin will help to avoid these unpleasant symptoms. These two components, being in one preparation, mutually enhance their effect, and rutin additionally protects ascorbic acid from oxidation.

In addition to the prevention of vascular disorders, Askorutin is shown to patients who use anticoagulants or non-steroidal anti-inflammatory drugs that thin the blood. Such remedies can increase the permeability of the vascular wall, and Ascorutin successfully counteracts this. Ascorutin should be used one tablet 3 times a day, regardless of meals. Produces Askorutin domestic Pharmstandard, and the average cost of one pack of 50 pills is only 50 rubles.

Advantages and disadvantages

The big advantage of Ascarutin is its low cost, pleasant sweet and sour taste, and few contraindications. These are hypersensitivity, childhood age, diseases such as thrombophlebitis and inflammatory vascular lesions. Ascarutin is not used in the first trimester of pregnancy. In rare cases, there may be side effects in the form of allergic reactions, or headaches, but when properly prescribed, the drug is well tolerated.

Panangin

Rating: 4.8

It is a favorite drug to compensate for magnesium and potassium deficiencies. These elements associated with asparagic acid (that is, in the form of aspartate) are known to improve nutrition of the heart muscle, and this optimizes cardiac output and minute volume of circulation. In the case of a deficiency of these substances, a person is prone to high blood pressure, atherosclerosis of the heart vessels develops, myocardial nutrition deteriorates. Panangin is shown not as an independent treatment, but as an additional drug in the treatment of patients with heart failure, with postinfarction cardiosclerosis, with the development of ventricular arrhythmias, as well as when prescribed diuretics, and especially diuretics such as furosemide, which actively withdraw potassium and magnesium from the body.

Panangin should be taken after meals, the average dosage is one or two tablets three times a day. The duration of the course is related to the peculiarities of the treatment of the underlying heart and vascular disease, so the duration of the course is determined by the attending physician. Panangin is produced by the Hungarian company Gedeon Richter, and one pack of 50 pills will cost an average of 160 rubles.

Advantages and disadvantages

The advantage of Panangin will be its low price and good effect related to the improvement of heart function in cases of actual potassium and magnesium deficiency. But it will be contraindicated if there is an excess of these compounds in the body, or there is an obstacle to their excretion through the kidneys, that is, acute and chronic renal failure. This medicine is contraindicated in myasthenia gravis, Addison’s disease, and in some heart rhythm disorders, such as atrioventricular blockades.

Therefore, the primary indications for prescribing Panangin should be determined by the attending physician. This medicine is not prescribed for pregnant and breastfeeding women or young children. But most often, the situation associated with chronic vascular disease occurs in people of mature, and even elderly, who have a deficiency of potassium and magnesium in the diet. That’s why it is actively prescribed by general practitioners and cardiologists. This drug improves quality of life and strengthens the cardiovascular system for very little money.

Energy and cell membranes

Especially popular not only among patients with various diseases of the heart and blood vessels, but also among healthy patients, and even among athletes, are vitamins that can improve energy metabolism of cells, and keep in order the lipid layer of membranes that are part of any cell. These are drugs that contain Coenzyme Q10, or ubiquinone, Lecithin, l-carnitine, which helps with heavy exercise, and taurine compounds. Let’s consider popular remedies that are designed to protect the cardiovascular system during stress and some diseases.

Kudesan Q 10 Forte

Rating: 4.8

Kudesan in drops, produced by the domestic company VneshtorgPharma, contains ubiquinone. Also called coenzyme Q10, or Coenzyme Q10. This molecule is essential in the active transport of electrons in the mitochondria, ubiquinone is a provitamin that significantly improves tissue respiration, and increases the production of ATP, and it is a universal energy donor within the cell. By the way Kudesan contributes to the stabilization of cellular lipids, they are not destroyed by various free radicals, and are not subjected to peroxidation. In healthy people ubiquinone improves vascular health and ECG values. When it is used systematically the tolerance to physical activity improves.

Kudesan is indicated for diseases such as hypertension and angina pectoris, chronic heart failure. It is also suitable for people without a heart or vascular condition but who are at risk of overexertion.

It is prescribed once a day, 15 drops for adults as a prophylactic. Course duration – from 2 to 3 months. As for the treatment, the dosage in drops is somewhat higher, but it is not given here, because it is up to the doctor to prescribe Kudesan for treatment. The cost of one bottle of 20 ml is on average 350 rubles.

Advantages and disadvantages

Cudesan is well tolerated, and of the side effects, allergic reactions are quite rare. At the same time, Kudesan as a vitamin for blood vessels has a large list of indications in children, and is used from the age of one year. In children it is shown in the complex treatment of chronic pyelonephritis, kidney damage, in hereditary diseases associated with degenerative processes, with muscular dystrophy and congenital myopathies. Kudesan is indispensable as a preventive measure before the upcoming heart surgery and major vascular surgery, such as aortocoronary bypass surgery. On the other hand, the form of release in drops is not entirely convenient, and in some cases Kudesan may interact with other drugs that take a patient, so it must be prescribed by a doctor.

Lecithin (granules)

Rating: 4.7

Lecithin was first isolated from egg yolk and is a mixture of phospholipids with triglycerides. Lecithin is a component of many components, primarily of cell membranes, including the vascular endothelium. It actively participates in the liver and lungs, regulates the synthesis of bile, and in the cardiovascular system Lecithin can stabilize the level of fats – triglycerides in blood plasma, and withdraw excessive atherogenic fractions of cholesterol from tissues and blood vessels. Lecithin is used in the complex prophylaxis of atherosclerosis, together with hypolipidemic drugs. In addition, lecithin is prescribed for pregnant and nursing women, because this substance is part of the nervous tissue of the baby. It is indicated for lecithin, for high body weight, for chronic vascular insufficiency, and for various diseases of the central nervous system. It must be used at a rate of 1 pellet 2 times a day, and the cost of a pack of 250 grams, produced by the German company Pro Vista, is a decent amount – 1126 rubles.

Advantages and disadvantages

The advantages of Lecithin are a wide range of indications, the possibility of prescribing it for the prevention, as well as pregnant and lactating women. It has very few contraindications, is able to actively prevent atherosclerosis, improve phospholipid metabolism, nerve impulse transmission. But at the same time, good quality Lecithin obtained from the best varieties of soybeans is quite expensive.

L – Carnitine Maxi (Solgar)

Rating: 4.7

Many believe that carnitine is only necessary for athletes who experience high physical exertion, and this tool is necessary for the breakdown of fat. But in fact, the situation is slightly different. Pure L-carnitine is really involved in energy metabolism, and it is consumed during various activities, both physical and mental. Rational burning of fat when injected into the body with L-carnitine not only allows you to reduce body weight during exercise, but also to destroy the reserves of lipids that exist in the lumen of blood vessels and are the precursors of atherosclerotic plaques.

In the case that the patient has hyperlipidemia, it is quite possible to use L-carnitine. It is indicated for amino acid deficiencies, in adulthood and old age to improve concentration, in patients with chronic circulatory disorders. Carnitine is produced by the American company Solgar, and the cost of this drug is quite high. A bottle of 30 tablets of carnitine, which is designed for 1 month of use for adults, will cost an average of 2000 rubles. This drug is the most expensive in the entire ranking of vitamins for blood vessels and heart.

Advantages and disadvantages

The high cost and the relative scarcity of products of this company limit the widespread use of L-carnitine. This vitamin for blood vessels and membranes can reduce the severity of bad cholesterol in the blood plasma, improve performance, and reduce fatigue. Contraindications to the appointment may be nervous condition, agitation and insomnia, and it is better to apply this tool in the morning when you have a whole day ahead for an active and full life.

Drugs of “big medicine”

Finally, at the end of the list dedicated to the health of the heart and blood vessels, consider some drugs that are most often used in the treatment of various diseases, but have recently also been used for prevention in the initial stages of varicose veins, with elevated cholesterol, and with the deposition of cholesterol plaques in the blood vessels.

They are an energy donor – Riboxin, a myocardial protector – Preduktal and a drug to improve blood flow Cardiomagnil, agents for the prevention and treatment of thrombosis, including for covid-19 infection.

Riboxin

Rating: 4.8

Riboxin’s middle name is inosine, and it is used as an anabolic nonsteroidal compound. It dilates the heart vessels, and has antiarrhythmic effect. Riboxin used to be prescribed for myocardial infarction and angina pectoris, for exercise-induced heart muscle dystrophy. Currently, Riboxin is widely used for prophylaxis, especially in people who experience these very increased physical exertion, such as athletes. Riboxin should be prescribed at 200 mg 2 times a day, the course of treatment is 10-15 days. Produces Riboxin in tablets pharmaceutical company Biochemik, and its cost is low. For 50 pills you can pay 50 rubles. This is one of the lowest rated drugs in our ranking.

Advantages and disadvantages

A disadvantage of Riboxin, like many metabolic compounds, is their inability to cope alone with any disease, especially with severe myocardial dysfunction, in intoxication, and severe metabolic disorders. But in the case when Riboxin is used in conjunction with properly chosen therapy, then the heart and blood vessel diseases are milder, unpleasant symptoms are reduced, and the cost of this product is very affordable, and it can be used almost without restrictions, it is contraindicated only for gout.

Preduktal OD (Rimecor)

Rating: 4.8

This medication is widely used as a protector of blood vessels and heart muscle against hypoxia, that is, oxygen deprivation, and contains trimetazidine. It is packaged in special capsules with prolonged release. From these capsules, the active ingredient enters the body at a constant rate, and slowly. Acts Trimetazidine to prepare cells to reduce their level of activity under hypoxia. If the decrease of oxygen in the blood takes the cells by surprise, their structures begin to break down, membrane and ion channels are blocked, and the sodium/potassium ratio changes. The use of trimetazidine helps minimize all of these pathological processes, preparing the cell for hypoxia by reducing the concentration of internal adenosine triphosphate.

Preduktal is indicated in patients with various diseases of the cardiovascular system and in some cases for the prevention of arterial hypertension, high cholesterol and other categories of patients. Preduktal is produced by the French company Servier laboratory. One pack of 30 capsules for a month of treatment costs 937 rubles. Used Preduktal one capsule daily, in the morning, with meals.

Advantages and disadvantages

The advantage of this trimetazidine is its good protection of the heart muscle and large vessels from hypoxia. After all, hypoxia is a universal pathophysiological mechanism that occurs in so many conditions, and not just in sick people. It protects well, but there are also some contraindications. For example, it is not recommended to be taken in cases of renal failure, in elderly people over 75 years old, in patients with severe liver disease, in people with Parkinson’s disease, tremor, and those under 18 years old. Preductal is not prescribed for pregnant and lactating women. Also, this remedy is quite expensive, but in the case where the patient really has a severe cardiovascular disease, Preduktal is one of the best drugs to support the patient.

Cardiomagnil

Rating: 4.8

Finally, to conclude the review, consider the most popular “cardiac aspirin,” or Cardiomagnil. Quite a long time ago, doctors discovered that low doses of aspirin, or acetylsalicylic acid, can thin the blood, or reduce platelet adhesion. Such drugs were called antiaggregants, or disaggregants. This includes Cardiomagnesin.

It is used extremely widely for the prevention of cardiac and vascular disease. It is thrombosis if there are serious risk factors, such as diabetes, high cholesterol, or high blood pressure. Cardiomagnil is indicated for the prevention of vascular accidents in overweight, smoking. Usually it is prescribed in a dosage of 150 mg on the first day, and then in a dose of half as much – once a day. The drug has an enteric form, and, according to the manufacturer, it has no harmful effects in the stomach, and does not contribute to ulcer formation. Produces Cardiomagnil by the German company Takeda, and the cost of one pack, designed for a month of treatment and consisting of 30 tablets, is 138 rubles.

Advantages and disadvantages

The advantage of Cardiomagnanil and other “cardiac aspirins” would be the well-known and proven effect of preventing vascular accidents. It really improves blood flow, and is indispensable in the complex treatment of various diseases, and as a means of prevention. But in some cases you need to be wary of side effects, because sometimes there is an intolerance to aspirin, aspirin asthma. It is also absolutely contraindicated in children and adolescents under 12 years of age because of possible Reye’s syndrome and in people with underactive blood clotting, like thrombocytopenia or haemophilia. Therefore, only if Cardiomagnil is prescribed by a doctor, it will significantly benefit you and the health of your blood vessels.

Vinpocetine (Cavinton Comfort)

Rating: 4.7

To Cavinton is quite applicable proverb: “an old horse won’t spoil a furrow”. It is a modified alkaloid of periwinkle, which has a positive effect on cerebral blood flow. Cavinton was previously used in tablets of 5 mg, as well as a solution for parenteral, intravenous administration. Then, after several years, it was found that the 10 mg dosage was more effective, and faster results came than when taking 5mg.

This kind of Kavinton became known as Kavinton Forte. This variety is called Cavinton Comfort, and the difference is purely for convenience: Cavinton Comfort is a dispersible tablets, with an orange flavor, which can not be drunk with water, and sucked up in the mouth. This sublingual administration, when the tablet is placed under the tongue, is also useful because the active substance is immediately absorbed from the sublingual vessels into the blood, bypassing the liver. Therefore, the action of the drug comes more quickly, and the drug has an effect at a lower concentration.

Cavinton Comfort in the form of dispersible tablets of 10 mg #30 is produced by the famous Hungarian company Gedeon Richter. Price from 175 to 300. rubles. for the beginning of 2021.

The drug is indicated in various neurological diseases, in the treatment of the effects of strokes, dementia, atherosclerosis, hypertensive encephalopathy. Ophthalmologists use Cavinton in the treatment of retinal vascular diseases, ENT doctors – for the treatment of tinnitus, that is, tinnitus and Meniere’s disease. It is necessary to take 10 mg 3 times a day, up to a daily dose of 30 mg, that is, the maximum.

Advantages and disadvantages

The advantage will be the convenience of admission, many years of research, good tolerability of the drug, the ability to apply it parenterally. However, the drug also has some side effects, of which the most frequent were abdominal discomfort, headache, but with a frequency of no more than 1% of patients. The drug should not be used in pregnant and lactating women, or persons under 18 years of age. Cautiously prescribes Cavinton when the QT interval is prolonged on the cardiogram. Intravenous Cavinton should be administered slowly, dropwise.

Detraleks (diosmin + hesperidin)

Rating: 4.7

This drug is produced by the French company Servier, and 30 tablets of 500 mg will cost from 660 to 800 rubles. Detralek belongs to the family of phlebotonics, or venotonics. These are drugs that act on the venous vessels, including the venules and venous parts of the capillaries.

Detralex, consisting of two natural components, diosmin and hesperidin bioflavonoids, increases the tone of the walls of the venous vessels and reduces their volume. It leads to improvement of work of venous valves, vascular permeability is reduced. The liquid part of the blood, i.e. plasma, does not flow through blood vessels, and does not escape into the tissues. Thus, Detralex prevents edema in the legs in varicose veins as a manifestation of chronic venous insufficiency of the lower limbs.

Besides, taking Detralex prevents the appearance of edema and heaviness in the legs, and this prevention is especially good in combination with venotonics and compression knitwear of zero degree of compression. It is prophylactic and can be bought without a prescription. Detralex is also used as a remedy for exacerbation of hemorrhoids, and pelvic vascular disease in women. Appoint the drug once a day by 500 mg, the course of treatment may be several months on the recommendation of the attending physician. In case of exacerbation of hemorrhoids, the dosage is much higher.

Advantages and disadvantages

Diosmin and hesperidin are effective bioflavonoids that are combined in one drug. If necessary, there is also a dosage of twice as much, in 1000 mg. Detralex has data from clinical studies, reduces symptoms of lymphatic and venous insufficiency, and has few side effects. Commonly there are gastrointestinal symptoms: loose stools, dyspeptic complaints, and sometimes nausea. Also Detralex is contraindicated for pregnant and lactating women.

Tanacan

Rating: 4.7

Another popular drug to improve microcirculation, manufactured by the French company Beaufour Ipsen, containing the well-known extract of Ginkgo biloba, or ginkgo biloba leaves. There are many different Ginkgo biloba supplements on the market, but Tanakan has high purity and proven efficacy in effecting improvement of hearing in patients with chronic sensorineural hearing loss.

One tablet contains 40 mg of Ginkgo biloba extract, the product is also available as a solution for oral administration, the solution is brown in color with a characteristic odor. The cost of a set of 90 tablets, from 1300 to 1600 rubles. The indication for prescribing Tanacan would be various cerebral vascular diseases, cognitive deficits, dementia, obliterating vascular disease of the lower extremities with intermittent claudication, hearing and tinnitus disorders, dizziness and vascular visual disturbances. The drug should be taken one tablet 3 times a day after meals. Minimum price course of treatment – at least 3 months. It is also used in ophthalmology. Link to literature review on the use of Tanacan in ophthalmology.

Advantages and disadvantages

The advantage of this drug is good tolerability, minimal side effects. Of contraindications – ulcer in the acute phase, acute heart attack and stroke, pregnancy, lactation and age under 18 years. The disadvantages of Tanacan include a long course of treatment, as well as the need to use it in the vast majority of cases in combination therapy with other drugs.

Curantil

Rating: 4.7

Dipyridamole, or Curantil is a more serious drug used in cardiology. It is produced by a German pharmaceutical company Berlin-Chemie, and a pack of 120 tablets in 25 mg dosage will cost you from 800 to 1500 rubles.

What dipyridamole does? It inhibits platelet aggregation, thinning the blood and improves the ability to microcirculate, that is, activates blood flow in the capillaries. But unlike other drugs, dipyridamole does not dilate large vessels, such as myocardial vessels, which is quite important.

The drug is indicated for the prevention and treatment of ischemic strokes, coronary heart disease, especially in cases of aspirin intolerance. Curantil is good at preventing thrombosis, both arterial and venous, and is used in the treatment of its complications. Dipyridamole is indispensable in cardiac surgery, after the prosthesis of heart valves it can prevent thromboembolic complications. It is also used for the management of pregnant women as a means of preventing placental insufficiency.

Curantil also has a mild immunogenic effect, and is capable of interferon induction, so it is used even for prevention and nonspecific treatment of influenza. It should be prescribed in different dosages. For example, if you have coronary heart disease – three tablets three times a day, that is almost 10 tablets a day. Although there are a lot of tablets in the pack, 120 mg/kg, it is not recommended for children., The dosage regimen may be sufficient for less than 2 weeks. It should be taken on an empty stomach with some fluids.

Advantages and disadvantages

The drug is able to really treat and prevent thrombosis and is a reliable aid to cardiac and vascular surgeons. However, you must remember that it is contraindicated in severe arterial hypertension and severe arrhythmias, in liver and kidney failure, in decompensated heart failure, in widespread vascular atherosclerosis, as well as in acute heart attack.

Curantil has a long and well-known history. In the world science has more than 10 thousand articles, reviews, studies and meta-analyses on dipyridamole.

And in case of coronavirus infection it is used, reducing severe hypercoagulation.

Dipyridamole as well as other anticoagulants should not be used in hemorrhagic syndrome and in the presence of an increased risk of bleeding. It is used in pregnant women according to special schemes, when there is a threat of feto-placental vascular thrombosis. If treated, or take Curantil, as a means of prevention, it is better not to drink tea or coffee at this time, because the xanthines contained in these drinks can reduce the effect of Curantil. It’s also a big plus that it can be prescribed to children from the age of 12.

Rivaroxaban (Xarelto)

Rating: 4.7

Finally, for the last remedy for the treatment and prevention of vascular disease, we will consider the most expensive, and most popular at the turn of 2020-2021, the drug rivaroxaban, or Xarelto (Bayer, Germany). The cost of a pack of 28 tablets for a month course varies within the range of 3000 roubles (about USD 5,000). What this drug is?

The active ingredient inhibits the active form of Factor Xa, or Stewart-Prauer, with high selectivity and directly. This factor plays a key role in the clotting and thrombin formation cascade. Thrombin leads to fibrin clots, and triggers platelet activation. A single molecule of factor Xa can affect the formation of 1,000 molecules of thrombin, and this can lead to massive clotting within the blood vessels. If this factor is blocked in time, a thrombin “explosion” can be avoided. This medication is indicated for stroke prevention, especially in patients with atrial fibrillation, for treatment of deep vein thrombosis, and for thromboembolism. The drug should be used with meals in 1 tablet, 15 or 20 mg, but no more than 20 mg for 1 day. More information about rivaroxaban can be found here.

Advantages and disadvantages

Xarelto, like Curantil (but especially Xarelto) has found its use in the case of covid pneumonia. It was then that one of the key factors in increasing the area of lung injury, risk of cytokine storm, and progression of acute respiratory failure was the massive appearance of intravascular microthrombosis in pulmonary tissue. They then led to the emergence of necrotic areas, on which, without ventilation, the formation of foci of secondary, bacterial pneumonia occurred. About the management of patients at MONIKI here.

However, the reliable anticoagulant effect also entails some side effects. For example, the occurrence of bleeding and anemia the occurrence of dizziness and headache, bleeding in the eye and conjunctiva, tachycardia, decreased blood pressure, bleeding gums and nosebleeds, pain in the extremities and skin itching. Taking the drug in high doses for a long time may even cause hematuria, which is the appearance of blood in the urine, menorrhagia – painful heavy menstruation, and even fever. It is clear that this treatment must be monitored by a knowledgeable professional.

Naturally, from the contraindications stand out separately hemorrhagic syndrome, bleeding, low blood clotting, already taking any anticoagulants, severe liver function disorders, in which coagulating proteins are not synthesized. Finally, these are pregnant and lactating women, as well as teenagers and children under the age of eighteen. There are also different drug-drug interactions, and this is quite an impressive list. For example, this drug is not compatible with the antifungal agent ketoconazole. It is also better not to use it with aspirin, there are other “subtleties” that are fully understood by the doctor.