- The key to allergic rhinitis
- Allergy drops: what they are?
- Rating of the best nasal allergy drops copy
- Nasal allergy drops (intranasal drops and sprays)
- Levocabastine (Tizin Alergy)
- Advantages and disadvantages
- Azelastine (Allergodil)
- Advantages and disadvantages
- Oxymetazoline (Afrin, Nazivin, Oxyfrin, Rhinostop extra, Sialor Rhino)
- Advantages and disadvantages
- Dimethinden + phenylephrine (Vibrocil, Bebifrin)
- Advantages and disadvantages
- Beclomethasone (Nasobek, Allergorus, Rinoklenil)
- Advantages and disadvantages
- Mometazone (Nazonex, Desrinit, MOMAT Rhino, Momesal Allegro, Momenza)
- Advantages and disadvantages
- Budesonide (Tafen Nazal)
- Advantages and Disadvantages
- Acylcysteine + tuaminoheptane (Rinofluimucil)
- Advantages and disadvantages
- Ipratropium bromide + oxymetazoline (Xymelin Extra)
- Advantages and disadvantages
- (Sea water) Aqua Maris
- Advantages and disadvantages
*Review of the best according to the editors. About the selection criteria. This material is subjective, it is not an advertisement and does not serve as a guide to purchase. Consultation with a specialist is necessary before purchase.
The most rapid effect, rapid relief of symptoms of allergic rhinitis have so-called organotropic (intranasal) agents: drugs in the form of nasal drops. Listed below are the most effective and popular nasal drops from allergies for adults and children.
The key to allergic rhinitis
There are exceptionally healthy people in the world. There is probably not a single adult in the world, and no adult who has not at least once in their life encountered a common rhinitis, or inflammation of the mucous membrane of the nose. Most often rhinitis, or household “runny nose”, is associated with acute respiratory viral infections, acute respiratory viral infections, with hypothermia, and is a local reaction of the upper respiratory tract to viral or microbial aggression.
But allergic rhinitis is still a little rarer than the common “cold”, and it has its own distinctive symptoms and signs. Scientists believe that at least one fifth of the world’s population (which is more than 1 billion people) have experienced symptoms of allergic rhinitis at different stages of their lives. man.
In the chronic course of allergic rhinitis, with annual recurrence of symptoms, or even more frequent symptoms, it can transform into a more serious pathology. So, half of the patients may subsequently develop bronchial atopic asthma, and if we take children with asthma, then about 70% of them regularly suffer from some signs of allergic rhinitis.
Allergic rhinitis contributes to the emergence and other ENT-organ diseases: for example, there are various forms of sinusitis, sinusitis develops, children begin to appear adenoid growths, resulting in requiring surgery. Often occurs against a background of chronic allergic rhinitis and middle exudative otitis (due to mucosal swelling of the tympanic cavity), which may be recurrent and with a lack of immunity to turn into a purulent form of middle ear inflammation.
Finally, in children, who generally have much more fluid than adults and more tissue prone to edema, the 10% of children with allergic rhinitis may occasionally have various laryngeal diseases, including life-threatening recurrent stenosis, the so-called false croup.
The most up-to-date recommendations for the treatment of allergic rhinitis and its impact on asthma (WHO ARIA, or Allergic Rhinitis and its Impact on Asthma) from 2020 can be foundin the largest electronic database of medical and biological articles, papers, and research in the world, at Pubmed, here.
It is known that the allergic reaction arising from the nasal mucosa appears not only due to the secretion of such a major biogenic amine as histamine. In the induction and maintenance of this reaction also take part such important mediators of allergy, inflammation and other effects as prostaglandins, serotonin, leukotrienes, kinins, leukocyte chemotaxis factors, arachidonic acid metabolites.pRead more about allergic rhinitis and its pathogenesis (development)here.
Allergy drops: what they are?
An allergic, even local, reaction is never formed by the body from any one action, or one simple biochemical reaction. This is a whole cascade involving many dozens or even hundreds of molecules, varieties, many cells, immunoglobulins. Vascular permeability changes, sensory nerve reactivity changes.
Therefore, antiallergic agents always belong to different groups of drugs, and they have several points of action. For example, vasoconstrictor nasal drops, which are related to anticongestants, reduce nasal discharge by narrowing blood vessels, and may help with allergic reactions. Antihistamine drops in the nose very quickly reduce itching, lacrimation. As a consequence, the blood flow to the mucosa is reduced, and therefore antihistamine drops reduce mucosal redness, irritability, and improve the patient’s comfort.
Finally, the most powerful anti-inflammatory and anti-allergic drugs are considered the reserve drugs ─ these are corticosteroid hormones. They are also used in the form of drops for nasal injections, they are on this list. Since an allergic reaction is not possible without the production of histamine, the tissue basophils, the so-called mast cells, also take part in this process. They produce histamine, and it takes a very lively part in the formation of the allergic reaction, and the buildup of edema.
Therefore, if the mast cells are prevented from secreting this biogenic amine, the allergic reaction will either not develop at all, or will be only mild. This requires the stabilization of the membranes of the mast cells, and for this purpose there is a special group of drugs, based on cromoglycic acid. This is another variety of both pills and intranasal allergy drops.
For the treatment of acute and chronic allergic rhinitis, many topical medications have been created, the main of which are administered locally, that is, intranasally. Among them stand out antihistamines, glucocorticosteroid hormones, decongestants, which contribute to the release of nasal secretions, separately stand out intranasal cromones and ipratropium bromide.
These drugs affect in different ways. Intranasal corticosteroid hormones are the strongest agents that reduce rhinorrhea, that is, the discharge of discharge, reduce itching, nasal congestion and sneezing. True, corticosteroid hormones do not take effect immediately, and on average, 12 hours after the first application, but the effect can last up to 12 hours or longer.
The rule of thumb: do not prescribe intranasal hormones right away if you can try to manage your rhinitis symptoms by other means. Hormonal medications should be in relative reserve, and should only be prescribed immediately if the course of the disease is severe. Remember that the body gradually gets used to hormones that are administered even locally.
Intranasal decongestants, which are usually alpha-adrenomimetics, are superior to corticosteroid hormones in terms of freeing the nose of secretions, and returning free breathing. Modern decongestants begin to act as early as 5 minutes after introduction into the nasal cavity, their duration can also last up to 8-12 hours, but they may have side effects common to adrenoreceptor agonists, among which are most often the appearance of palpitation, increased blood pressure, other signs.
Intranasal antihistamines have very little effect on nasal congestion, but they are good for stopping sneezing, itching, and rhinorrhea, and take effect within 15 minutes. Preparations such as ipratropium bromide and intranasal cromones are used in combination therapy. Ipratropium bromide reduces rhinorrhea, and has little effect on other symptoms, intranasal cromones act on many symptoms, but slightly, but also greatly increase the effect of other medications when prescribed together.
This review will look at intranasal drops and sprays intended to treat allergies. Each medication has an international nonproprietary name (INN) which appears in front of the sequential number. Substances are listed in parentheses, only in the form of trade names of various manufacturing companies. As a rule, the first number goes to the most expensive, usually original drug, and then, if available, – commercial copies, or trade names of the drugs themselves.
This list is not an advertisement or an invitation to sell. Any medical means, even simple nasal drops, should be prescribed by a doctor according to the indications and the presence of contraindications. All information about these medications is available in the public domain, and is taken solely from the official instructions for use.
For all drugs listed above, the price range is valid for pharmacies of all forms of ownership in the Russian Federation for February 2021. All the listed drugs are recommended for regulation of allergy symptoms by the national and international clinical guidelines and the relevant protocols for treatment of acute and chronic allergy syndromes.
Rating of the best nasal allergy drops copy
Nomination | Location | Name | Price |
Nasal allergy drops (intranasal drops and sprays) | 1 | Levocabastine (Tizin Alergy) | 477 € |
2 | Azelastine (Allergodil) | 383 € | |
3 | Oxymetazoline (Afrin, Nazivin, Oxyfrin, Rhinostop extra, Sialor Rhino) | 231 € | |
4 | Dimethinden+phenylephrine (Vibrocil, Bebifrin) | 287 € | |
5 | Beclomethasone (Nasobec, Allergorus, Rinocleanil) | 185 € | |
6 | Mometasone (Nazonex, Desrinit, Momat Rhino, Momesal Allegro, Momenza) | 465 € | |
7 | Budesonide (Tafen Nazal) | 313 € | |
8 | Acylcysteine + tuaminoheptane (Rhinofluimucil) | 313 € | |
9 | Ipratropium bromide+xylomethasoline (Ximeline Extra) | 209 € | |
10 | (Sea water) Aqua Maris | 241 € |
Nasal allergy drops (intranasal drops and sprays)
In the case of intranasal drops and sprays, many nasal products are duplicated by the corresponding eye drops, because they act in the same way: both have either the mucosa or the sclera and conjunctiva. Even the concentrations of active ingredients are quite similar, and the product lines are the same. There are Allergodil for eyes and Allergodil for nose. There is Lecrolin for the eyes, and there is Cromohexal for the nose.
In some variants, allergy nasal drops even bear the same name as eye drops. But we have tried to avoid repetition, and keep the originality for intranasal drops dedicated to allergies. Regarding pathogenetic characteristics, among intranasal drops for allergies, we will consider:
- Corticosteroid hormones such as fluticasone propionate, triamcinolone acetonide, mometasone furoate, budesonide, flunisolid, beclomethasone dipropionate;
- Antinoconstrictor vasoconstrictor drugs (α1-adrenomimetics, α2-adrenomimetics, pronoradrenalins, norepinephrine decomposition inhibitors);
- Modern second-generation antihistamines (acelastine, levocabastine);
- Antihistamines with decongestant effect: Vibrocil;
- Anticholinergic drugs: ipratropium bromide.
Also in this short review, we will consider nonspecific nasal mucosal moisturisers which are used intranasally. Specific immune therapy drugs, or SIT-therapy, are prescribed by an immunologist-allergologist after identifying those allergens that provoke regular or sporadic attacks of allergic rhinitis.
For those who want to understand more, a link is given.These are the Federal Clinical Guidelines of the Russian Association of Allergists and Clinical Immunologists, on the diagnosis and treatment of allergic rhinitis.
Levocabastine (Tizin Alergy)

Tizin Alergy is produced as a nasal spray by the Belgian division of the well-known company Janssen, and a 10 ml bottle will cost from 310 to 410 rubles. It is a dosage spray, contains levocabastine hydrochloride, and refers to anti-allergy drugs, histamine receptor blockers (H1). This product is long-lasting, and after spraying in the nasal cavity, it quickly stops sneezing, nasal itching and nasal discharge. Tizin Alergy works quickly: already in 5 minutes relief comes, and the action of the product lasts up to 12 hours. The drug should be dosed into each nostril in 2 doses for adults, (i.e., 2 “squirts”), twice a day. The remedy should be used until the symptoms are gone, you can even use 3-4 times a day. It is very important to clear the nasal passages beforehand, blow your nose well, and take a breath while injecting. Shake the bottle before each use.
Advantages and disadvantages
The advantages are the rapid onset of the effect, and the possibility of symptomatic treatment of both year-round and seasonal rhinitis, it is desirable for a patient with severe allergies to carry a vial with them. However, this product is undesirable for children under six years of age, pregnant and lactating women. Levocabastine may have side effects that depend on the dose. Headache, drowsiness, nausea, pain in the throat and larynx, fatigue were most commonly reported. The word “frequent side effect” refers to the occurrence of side effects in no more than 10% of all cases.
Azelastine (Allergodil)

Allergodil is another popular anti-allergy drug, from the same group of histamine receptor blockers. Allergodil is also available as a spray, it is produced by the German company Medapharm. However, this remedy is much more expensive than levocabastine: for the same bottle of 10 ml you will have to pay in February 2021 from 465 to 600 rubles.
Why is this medicine more expensive?? Its active ingredient, azelastine hydrochloride, not only immediately and permanently blocks the histamine receptors responsible for allergies and alleviates the condition. It also has a membrane stabilizing effect similar to that of cromones.
When administered intranasally, it can also reduce complaints such as nasal congestion, sneezing, and intense rhinorrhea well and quickly. It also works 10-15 minutes after intranasal administration, and is able to maintain its effectiveness for 12 hours and longer. Allergodil is indicated for the treatment of allergic rhinitis, rhinoconjunctivitis, as it is also available in eye drops, as well as for the relief of clinical symptoms of non-allergic rhinitis of a vasomotor nature.
This significantly extends its range of use, since vasomotor rhinitis may be a reaction to long-term use of adrenomimetics, and occurs with naphthisin addiction. In case of allergic rhinitis, it is necessary to apply it to adults and children from the age of six years, 1 dose 2 times a day into each nostril in the morning and in the evening. Also, adults and children over 12 years of age can be given 2 doses, which would be 0.28 ml or 280 mcg in each nasal passage twice a day. Allergodil can be used for longer periods, but in any case, it should not be used more than six months continuously. In the case of vasomotor rhinitis, the drug should not be used for more than two months.
Advantages and disadvantages
The advantage of this drug is its double effect, not only antiallergic, but also membrane stabilizing, as well as the possibility of using it for a long time. The remedy is practically not absorbed, and side effects occur much less frequently than to the previous drug, and their list is much smaller. But in the same way, it is contraindicated in allergic rhinitis in children under 6 years of age, and in case of vasomotor – under 12 years of age. But it should be taken into account that the remedy can also be used for other forms of rhinitis. It is not intended for pregnant and lactating women (no relevant studies), and no symptoms of overdose are observed.
Oxymetazoline (Afrin, Nazivin, Oxyfrin, Rhinostop extra, Sialor Rhino)

Oxymetazoline is represented by a variety of drugs, and it is currently considered one of the most promising and most convenient adrenomimetics from the group of anticongestants. If the “ancient ancestors” oxymetazoline, such as Naphtisin, did not act as quickly, and, conversely, quickly ceased to act, the oxymetazoline is able, after a single injection, to cause a permanent narrowing of the vessels of the nasal mucosa. Not only of the nose, but also of the accessory sinuses and Eustachian tube.
After one minute there is already a pronounced effect, which lasts up to 12 hours. Afrin drug is available as a nasal spray in a 15 ml bottle, produced by the Canadian company Contact Pharmaceutical, the cost of such bottles ranges from 190 to 220 rubles. At the same time, a significant number of varieties of oxymetazoline, both domestic and foreign manufacturers, are on the market.
Afrin should be used in adults with two to three injections into each nostril every 10-12 hours, which is very convenient. If necessary, it is possible to administer Afrin more often, after 8 hours, but it is advisable not to exceed the last dose.
Advantages and disadvantages
The advantage of Afrin can be considered its form: the nasal spray is not liquid, but rather thick and viscous. Therefore, when a person puts his head down after spraying, it does not drip down his throat or leak out of his nose. Viscous spray stays on mucosa, and then it shows a fast and strong effect. In addition, the drug has a pleasant citrus odor.
A significant advantage of this drug is not only the possibility of symptomatic treatment of various rhinitis, including infectious and allergic, but also the treatment of sinusitis and eustachitis, as well as the prevention of exudative otitis media, which was mentioned above.
The drug causes a minor side effect, especially if it is used very often: it is dryness and burning of the nasal mucosa, due to prolonged and persistent vasoconstriction. If Afrin is used for a long time, it can become addictive, and even atrophy of the nasal mucosa can develop. Therefore, it is contraindicated in atrophic rhinitis, children under six years of age, hypersensitivity and co-administration of MAO inhibitors such as nialamide.
General contraindications and special situations should be remembered: alpha-adrenomimetics can have a harmful effect on patients with IHD and angina pectoris, chronic heart failure, atherosclerosis, thyroid hyperfunction, glaucoma, and prostatic hyperplasia with possible urinary retention. But if the drug is used in short courses and according to the indications, it is very good and recommended for any home medicine cabinet.
Dimethinden + phenylephrine (Vibrocil, Bebifrin)

Vibrocil is the first complex drug in our review, which contains 2 components, dimethinden and phenylephrine. Dimethinden is everyone’s favorite, good old Fenistil, which can be used even in infants. It is a histamine receptor blocker, roughly from the same group as Tymedrol, Tavegil, Suprastin or the more modern representatives that we have already described: Allergodil and Tizin Alergy. The second ingredient, phenylephrine, is a vasoconstrictor, and has about the same effect as Afrin, only slightly weaker. It is a sympathomimetic that moderately stimulates vascular adrenoreceptors. Its task is to eliminate the swelling of the nasal mucosa and sinuses, and dimethinden reduces the manifestation of allergies, i.e. itching, sneezing and nasal congestion. Vibrocil is a drug that has no analogues produced in the Russian Federation. And it is produced by the well-known company Glaxosmithk
Since this drug is complex, the indications for its use are much broader, and are not limited to allergic rhinitis or hay fever alone. This is any acute rhinitis, including a cold and acute respiratory infections, forms of vasomotor and chronic inflammation of the nasal cavity mucosa.
Used Vibrocil and in the complex treatment of various sinusitis, such as maxillary sinusitis. It is indicated as an adjuvant for acute otitis media, reducing swelling of the eustachian tube mucosa, and preventing the accumulation of secretions in the tympanic cavity. In addition, Vibrocil helps ENT doctors, and is used as a means of preoperative preparation on the nasal cavity. And after surgery it can quickly eliminate the swelling of the nasal cavity caused by surgery.
As in other cases, the product is shown starting from six years of age. For children under 12 years of age, one to two doses may be injected into each nostril, up to four times a day. Exactly the same dosage for older adults as well. During injection, it is advisable to inhale through the nose, and before injection, as usual, you should clean the nasal passages as much as possible for free breathing. Use of the drug without a doctor’s prescription is limited to seven days.
Advantages and disadvantages
As you know, the more components the drug contains, the more there will be contraindications and side effects, to each of the ingredients. But in this case Vibrocil is well-balanced, with only rare side effects such as dry nose, burning and discomfort, and not more than 0.1% of all uses. However, Vibrocil should not be used in patients with nasal mucosal atrophy, patients taking monoamine oxidase inhibitors, children under six years of age with closed angle glaucoma, and hypersensitive patients. There are also the usual conditions under which means from the category of adrenomimetics should be administered with caution, but we have already written about them above.
Beclomethasone (Nasobek, Allergorus, Rinoklenil)

Let’s proceed to a review of some hormonal drugs that are considered “heavy artillery” and are intended for basic therapy of moderate and severe allergic rhinitis. The first of these drugs is the hormone beclomethasone, available as a dosed nasal spray. One dose contains 50 micrograms, a bottle of Czech production is designed for 200 doses, and costs from 160 to 180 rubles., Which is quite inexpensive. All of the following hormonal drugs are represented by metered nasal sprays, and almost all of them have a single dose, that is, one “squirt” weighing 50 micrograms, so we will not specify the composition of one dose anymore, it is common to all.
Nasobec is used, including for long-term treatment, to provide anti-inflammatory anti-allergic and even immunosuppressive action. In addition to reducing mucosal edema, the drug reduces the intensity of infiltration and inflammation. Nasobek is indicated, inter alia, for long-lasting seasonal and year-round allergic rhinitis. Apply it to both adults and children over 12 years of age, one to two doses in each nostril 2 times a day. The maximum daily dose is 400 micrograms. For children aged 6 to 12 years, the daily dose should be reduced, it is determined by the doctor. No dose adjustment is necessary for older adults.
It is very important to apply the medication against a clean nasal passages, and at the same time as administering a dose of the hormonal aerosol, you should inhale lightly through the passage where the medication is being sprayed. The remedy can be used for a long time, but the duration of treatment is determined by the doctor.
Advantages and disadvantages
Nasobek, like other hormonal drugs, reliably protect against the development of allergic symptoms, but side effects should be taken into account. Although this hormone is used topically, it is still a corticosteroid and can lead to increased intraocular pressure, the occurrence of upper respiratory tract candidiasis, but only when taken in high doses for a long time due to its immunosuppressive effect. Occasionally, a skin rash may occur. And if you abuse the hormone, you may also experience symptoms of adrenal insufficiency and increased bone fragility.
Nasobek is contraindicated in bleeding and hemorrhagic syndrome, frequent nosebleeds, against the background of tuberculosis of the respiratory organs and severe fungal and viral infections. Hormones are prohibited in the first trimester of pregnancy, as well as in cases of hypersensitivity. There are also special indications, such as recent nasal surgery, but the attending physician must inform the patient about this.
Keep in mind that Nasobek does not work immediately, and relief of rhinitis symptoms occurs after about a week. After the patient feels better, the dosage is reduced to the minimum. The immunosuppressive effect of hormones impairs wound healing, and if there are septal ulcerations or nasal cavity surgeries, this and other hormones should not be prescribed until the wounds are completely healed. There are other peculiarities that the doctor who prescribes hormonal drugs, even for topical use, must take into account.
Mometazone (Nazonex, Desrinit, MOMAT Rhino, Momesal Allegro, Momenza)

Another representative of a fairly strong hormonal drug for intranasal use is Nasonex, it contains the hormone mometasone, also in the form of a dosed nasal spray. The bottle contains 120 doses, and its cost is significantly higher: from 700 to 820 rubles. Manufactures Nazonex Belgian company Schering-Plough.
It is an intranasal medication, mometasone furoate. It successfully fights allergies and inflammations, and in studies with provocative antigens, which were applied to the nasal mucosa, the drug showed high anti-inflammatory activity, at the same time in different phases of allergic reactions. Nazonex is indicated for a variety of seasonal and allergic rhinitis year-round, for acute sinusitis, maxillary sinusitis, or exacerbation of a chronic process, starting at age 12, as well as for the prevention of allergic rhinitis and rhinosinusitis. It can also be prescribed in the presence of nasal polyposis, with nasal breathing disorders, in adults and persons from the age of 18 years (for polyposis only).
In adults, the drug is administered in a dosage of 2 injections into each nostril once a day; children may also be prescribed from the age of 2 years. In this case, one injection into each nostril once a day is required, so the total dose will be 100 micrograms. There are specific dosages for the treatment of sinusitis and nasal polyposis, which are determined by the doctor.
Advantages and disadvantages
It is important that this medicine can be prescribed to children from the age of 2 years. The most common side effects were nasal bleeding (due to nasal polyposis), typical of hormones with frequent use. Usually there were frequent upper respiratory tract infections (due to reduced immunity), headache, and some farting and irritation in the throat. Contraindications for use of the drug should be considered. These are recent nasal surgery, hypersensitivity, infection, hemorrhagic syndrome, and other conditions.
With long-term use of all intranasal hormones, patients should always be examined of the nasal mucosa to avoid the development of local fungal infection of the nasal cavity or oropharynx, because corticosteroids, despite all their pronounced effectiveness, reduce local immunity. An allergic reaction is a reaction of the immune defense, albeit perverse. And the occurrence of nasal candidiasis and respiratory viral infections – may be payback for the abuse of hormones.
Budesonide (Tafen Nazal)

Tafen Nasal is another hormonal medication that already contains budesonide. Some will ask: Why so many hormones? In fact, they differ, and primarily in the strength and duration of action. An experienced physician will not prescribe a stronger hormonal product right away, just as he or she would with a hormonal ointment, cream or gel. If hydrocortisone or betamethasone helps, why prescribe the “superpower” Dermoveit? Similarly, intranasal hormones.
This drug works in the same way, it is a powerful anti-allergy and anti-inflammatory drug, increases the number of adrenoreceptors in vascular smooth muscle and reduces the manifestation of allergic symptoms in the early and late phase of the reaction. At the same time against the background of taking Tafen-Nasal, there is a more rapid improvement of the condition: in 2-3 days after the start of treatment.
This means that all hormonal intranasal agents, without exception, are not used to relieve allergic rhinitis, as an “emergency” remedy. It is useless to use hormones if the patient is currently sneezing, coughing and nasal discharge is “running”. Hormones take time to work, but they are powerful for a long time.
Tafen-Nasal is produced in Slovenia, by the pharmaceutical company Lek, and one bottle containing 200 doses has an average cost, from 280 to 340 rubles. The drug can be used for the treatment and prevention of allergic and non-allergic rhinitis, as well as in cases of nasal polyposis. It is administered to adults, as well as children over 6 years of age. Two doses are prescribed at the beginning of the treatment, that is, 250 mg in each nostril twice a day. Then, after feeling better, it is possible to switch to a maintenance dose, which is half as much.
Advantages and Disadvantages
The drug has a fairly rapid onset of action, moderate cost, and good European quality. However, its side effects are exactly the same as those of other corticosteroids, from mucosal irritation and dryness to dizziness and impaired wound healing. The contraindications for use are the same, including those separately noted by the manufacturer for neurotropic viral infections (e.g., herpetic and tick-borne encephalitis), cirrhosis of the liver, and hypothyroidism. Certain medications, such as estrogens and anabolic steroids, can increase the effects of budesonide.
Acylcysteine + tuaminoheptane (Rinofluimucil)

This is also a complex drug to relieve the symptoms of rhinitis, but it contains no anti-allergic or non-hormonal components. What is in Rinofluimucil?? It is a mucolytic. Its job is to liquefy the viscous pus-mucous secretions in the nose, and it acts similarly to phlegm thinning drugs in the lungs. Nasal mucus is liquefied due to acylcysteine. As for tuaminoheptane, it is a light vasoconstrictor that does not belong to the adrenomimetics. Therefore, it should be used in those cases where it is difficult to achieve free nasal breathing against the background of rhinitis. It is administered to adults in 2 doses in each nostril 3-4 times a day, the course duration is no longer than 7 days without a doctor’s prescription. It is an Italian drug by Zambon and a 10 ml nasal spray costs from 280 to 330 rubles.
Advantages and disadvantages
By the way, many of the above remedies require that they be injected during a full and effective nasal inhalation. Therefore, the use of Rinofluimucil can be considered basic, and other nasal drops and sprays can be used on its background. In some cases, and Rinofluimucil itself can already relieve nasal breathing so that hormones or other drugs are no longer needed.
Ipratropium bromide + oxymetazoline (Xymelin Extra)

This wonderful medication is produced in Germany by the well-known company Takeda, and consists of two components. This is xylometazoline, which narrows blood vessels, exhibits alpha-adrenomimetic properties and ipratropium bromide, which refers to cholinolytics. This means that it slightly dries the nasal cavity mucosa, reducing the secretion of glands.
This medicine is indicated for all variants of swelling and hyperemia of the nasal cavity, with pronounced rhinitis, including acute allergic, with pollinosis and various types of sinusitis. The medicine is dispensed in doses, for adults one injection in each nostril 3 times a day is required, but not more often than after six hours. Do not use the drug yourself for more than a week, and then you must always consult a doctor. In case the patient feels better and the symptoms have subsided, it is advisable to stop using immediately, even if 7 days have not yet passed. This will minimize the risk of unwanted manifestations. The cost of one package of 10 ml nasal spray ranges from 180 to 220 rubles.
Advantages and disadvantages
Do not be alarmed by these recommendations, the manufacturer just monitors not only the sales of their product, but also the consumers’ health. Some of the side effects are: impaired taste and headache, dry and irritated eyes, possible increase in intraocular pressure, options of nasal bleeding or dry nose, dry mouth and other effects resulting from vasoconstriction and inhibition of mucosal gland secretion. There may also be systemic effects if the drug is abused. Contraindications are hypertension, severe atherosclerosis, hyperthyroidism and glaucoma, pregnancy, age less than 18 years, and the condition after transsphenoidal neurosurgical interventions.
(Sea water) Aqua Maris

It was mentioned a lot above that a side effect of many hormonal and vasoconstrictors, anticongestants can be dryness of the nasal mucosa, and with long-term use, even its atrophy. What can be used to relieve dryness? One of the best known preparations of the Croatian company Jadran is Aquamaris. In translation from Latin “aqua maris” translates as follows: water of the sea.
This is also a nasal dosed spray, and a small can of 30 ml, which will cost, on average, 250 rubles. It contains common seawater taken from a depth of approximately 100 m in an ecologically clean area of the Adriatic.
This seawater contains everything that ordinary seawater of the seas and oceans requires. It has a salinity of about 33 ppm. Standard dose of sodium cations, calcium magnesium, chlorine anion, sulfate and carbonate anion. The drug non-specific liquefies mucus, improves the function of the mucosal epithelium, stimulates and regenerates the nasal mucosa.
Aquamaris can also be used in healthy people for hygienic purposes, if you live in the city and most often encounter dry and dusty air of the premises. In addition, Aquamaris is indicated for nasal rinsing and gargling in acute and chronic pathology of ENT-organs, after surgery, in persons with sensitivity to drugs against various forms of rhinitis. It is used for the prevention of various colds and upper respiratory tract infections in the fall and winter. It is possible to use Aquamaris in persons working in air-conditioned rooms, in smokers, drivers, those working in hot and dusty workshops.
In this way, seawater can help you breathe comfortably. It can be prescribed even to infants, from the first day of life. And for adults, it is injected into the nasal passages for as long as necessary. And even if there is a significant excess of seawater, let it be removed with either a handkerchief or a tampon. You can even inhale it through your nose and spit it out through your mouth.
Advantages and disadvantages
Indeed, flushing the nasal cavity is very useful for adults and children. This eliminates dryness, congestion, and allows you to get rid of various pathogens. However, it is possible to replace seawater with soft water, lightly salted. Of course, if you live on a desert island, and you are surrounded by a clear ocean, then there is nothing easier than just sucking in seawater with your nose several times a day, It is very useful.
Yet a small bottle containing 30 ml of seawater would hardly be worth that much. For 250 rubles. It is possible to purchase a modern medication. If Aquamaris cost 30-50 rubles, the Russian buyer would buy it more willingly. In addition, our country is a Great Maritime Power, and the northern salty seas are even more environmentally friendly than the Adriatic, as shipping is much less developed in them. We have no doubt that the producers of Russian pharmaceutical products will soon establish the delivery of seawater from the Barents, Kara and Laptev seas, which will be more accessible for the average Russian and even more useful than the seawater from the Adriatic.