6 best medications for fatigue

*Review of the best according to the editors. About the selection criteria. This material is subjective, is not an advertisement and does not serve as a guide to purchase. It is necessary to consult with a specialist before buying.

Does a person need any medication or medication for fatigue? There seems to be a catch to such a question, and rightly so. After all, fatigue is as natural a concept not only for humans, but for all living creatures as vigor. Fatigue is as natural as the states of sleep and wakefulness, and the best remedy for fatigue is to rest fully.

Physiological fatigue can be defined as a feeling of muscular and mental exhaustion, satiety of one’s own activities, a condition that requires physical rest for the muscular system or long, normal sleep for recovery of the brain function. After a period of rest a healthy person, adult or child, feels a rush of physical strength, a readiness for action, or even the need to act, and the results of mental effort and the fruits of such intellectual labor are more complete than those of a tired and sleep-deprived person. These are all trivial truths: a healthy person does not need any medication for fatigue.

However, there are also forms of fatigue in which even a long, what seemed to be a good rest before, does not lead to the restoration of efficiency. The medical term for this condition is chronic fatigue syndrome.

This disease is quite difficult to diagnose, although its manifestations are very obvious. This physical and mental fatigue, inability to perform various kinds of work, rapid exhaustion. However, despite the simplicity of diagnosis, it can only be diagnosed “residually”, to the exclusion of all other causes of loss of strength. And this requires a lot of work for the doctor, and the use of different types of diagnostics: both laboratory methods and instrumental, as well as methods of psychological testing.

So do not think that if a patient does not have any reasons that “lie on the surface”, then we are talking about chronic fatigue syndrome. The reason may lie in something else entirely, for example, in a prolonged worm infestation, or in the hidden course of iron deficiency anemia. Therefore, before describing medications designed to combat fatigue, let’s understand what are the most common causes that can lead to this condition in the clinic of internal diseases.

Causes of loss of strength

The first thing that comes to mind is a lack of time for rest and sleep. A person who is constantly overworked, having too little time to fulfil their need for sleep and muscle rest, gradually becomes a victim of chronic fatigue syndrome. Which leads to a loss of strength? Here are the most common causes. By the way, fatigue and chronic fatigue syndrome should not be considered the same condition. As we will see below, CGF (chronic fatigue syndrome) has a slightly different origin, although of course the following causes also contribute to the development of CGF.

Sleep disturbance

A very important group of diseases that lead to lack of sleep, disrupted sleep phases, and insomnia. It is anxiety, different types of anxiety disorders and depression, the occurrence of periods of sleep apnea, when due to the low tone of the muscles of the larynx, pharynx, and soft palate, there is a periodic respiratory arrest.

And if the patient wakes up convulsively several times a night during the adrenaline rush, suffering from suffocation, then, of course, a good night’s sleep is out of the question. Obesity, cardiovascular disease, metabolic disorders lead to these sleep apneas. Such patients often suffer from diabetes mellitus and metabolic syndrome “X.

Nutrient deficiencies

The next group of diseases is insufficient intake of substances for plastic metabolism, or nutrients. It is a question of proteins, fats and especially – carbohydrates, or energy donors.

Of course, in modern civilized society we are not talking about forced and prolonged periods of starvation, when a person can hardly walk or, as they say, “starve to death”. It is primarily a matter of a monotonous diet, systematic consumption of fast food, sugary carbonated drinks, canned food, canned goods, sausages, cakes. Their diet is poor in fiber, vitamins, and trace elements. Patients suffer from chronic constipation, skin allergies, and intestinal auto-intoxication. Such “fast foods” and snacks, which are interspersed with long periods of reduced physical activity, are the key not only to chronic fatigue syndrome, but also to more serious diseases. Therefore, the life of the modern manager, or “office plankton”, consisting of smoking breaks, osteochondrosis, avalanches, constipation and muscle pain, very often leads to this disease.

Anemia

Of the clinical syndromes that quickly lead to the development of chronic fatigue are the anemia listed above. Recall that anemia is not just a “deficit” of iron, as sometimes thought. Anemia is a condition in which the volume of blood is reduced:

1. The amount of hemoglobin, that is directly the respiratory iron-containing pigment;
2. Hematocrit, that is, the number of form elements falls, primarily red blood cells, and there is hemodilution, or dilution of the blood.

Finally, there may be healthy, complete red blood cells in this unit of volume, but there are simply too few produced.

Anemia is not always accompanied by pallor, shortness of breath, and decreased exercise tolerance and other classic signs. Quite often anemic syndrome, which is limited in its manifestations to chronic fatigue, is expressed insignificantly, and it can only be diagnosed by laboratory methods.

“Caffeine addicts.”

Fatigue is also caused by increased exhaustion of central nervous system structures, caused by the negative feedback generated by caffeine and stimulant abuse. Yes, indeed, initially, with an adequate response, increased consumption of strong coffee and tea, especially green tea with jasmine, varieties of tea such as Puer, does lead to an increase in performance. But further, with the systematic continuation of the caffeine load, the body is deprived of the necessary time for recuperation, and soon it begins to refuse to work at this rate.

Of course, when abusing caffeine there is no addiction, but it is necessary to remember the risk of exhaustion, the emergence of cerebrasthenic syndrome and irritability.

In addition, excessive caffeine leads to myocardial dystrophy many years later, and remember at least the example of the Great Honore de Balzac, who created his tens of volumes of The Human Comedy, drinking throughout his life about 40,000 cups of strong coffee, as calculated by his biographers.

Chronic pathology

Finally, we can also think of other diseases. These are:

1. Chronic glial infestations;
2. Allergic manifestations, which are accompanied by skin itching and deprive a person of sleep;
3. Urological infections and sexually transmitted diseases with cutting and itching;
4. any signs of decreased cellular and humoral immunity: chronic forms of infectious diseases and carrier, HIV infection
5. malignant neoplasms;
6. Intestinal dysbacteriosis caused by taking antibiotics in the form of self-medication;

Of all the varied causes of chronic fatigue that have been listed above, absolutely all. And only when it becomes clear that the person does not have depressive episodes, no cancer pathology, he does not abuse tea and coffee, and he has no anemia and other diseases, then chronic fatigue syndrome can be diagnosed. What, after all, are its signs and criteria? Based on the “total absence of everything,” it is difficult to make any diagnosis.

How is the diagnosis of chronic fatigue syndrome?

Naturally, the diagnosis of such a symptom complex is based on numerous complaints. First of all, these are:

1. persistent, repeated absence of the feeling of morning vivacity after a seemingly good night’s sleep, this condition persists permanently;
2. on this background there can be sleepiness during the day, but even after intense physical activity the person cannot fall asleep easily and quickly;
3. Irritability and bad moods “out of the blue”;
4. memory and concentration problems; malignant neoplasms.
5. Then, several weeks and months later, such somatic symptoms as the following will join:
6. cephalgia, or headaches;
7. reduced resistance to infectious diseases, frequent sore throat and sore throat;
8. immunity tension decreases, which is manifested by intermittent lymphadenitis, mainly in the area of the cervical and axillary lymph nodes;
9. Sometimes there is diffuse muscular and joint pain – paroxysms of myalgia and arthralgia.

It is very important to accurately determine the duration of the disease. This pronounced decrease in performance and obvious fatigue, but without any identifiable disease, must last for at least 6 months. It is important that such symptoms are not explained, there are no reasons for them.

These are the so-called “big,” or obligatory criteria for this diagnosis. All other symptoms that have been described above are called “minor” criteria, and necessarily in the same patient there must be several, at least four. For example, it is the presence of muscle aches, irritability, sleep that does not bring rest and occasional sore throat, or the manifestation of pharyngitis.

Thinking people have probably already realized that the presence of infectious symptoms, that is, lymphadenitis, myalgia and arthralgia, and sore throat, do have something to do with infectious pathology, and this is indeed. Chronic fatigue syndrome is now thought to be an infectious, sluggish disease, and is most likely caused by either the Epstein-Barr virus or cytomegalovirus, type VI herpesviruses, or other non-cellular life forms.

However, despite the possible presence of a causative agent, the presence of risk factors can also be considered extremely important in the occurrence of long-term fatigue. Therefore, before proceeding to the description of the various medicines that return vigor, let us note what risk factors we know, and what we need to fight in the first place. After all, no medication can help the patient if he continues not only to treat, but also systematically worsens his own health.

Risk Factors

Let’s list those factors which provoke chronic fatigue, lead to a long course of somatic infectious pathology, and worsen the prognosis of any disease. In the first place, these are:

1. Unfavorable ecological environment;
2. The presence of chronic diseases – infectious, endocrine, inflammatory and autoimmune, and especially running hidden, creating a “background”;
3. low standard of living;
4. lack of sunlight, high latitudes;
5. increased emotional and physical strain;
6. a background of hypodynamia and a state of chronic stress;
7. constant exposure to electromagnetic radiation, computers, and gadgets;\
8. drug aggression and hypovitaminosis;
9. Improper and balanced nutrition;
10. Monotonous and strenuous work;
11. Psychological pressure: the lack of prospects in life;
12. Various bad habits, from smoking to domestic drunkenness, not to mention chemical drug addiction.

Now that we know about the possible causes, symptoms and the influence of risk factors, let’s start treating fatigue, but first let’s try to do without medication. The following measures may seem hackneyed and repeated dozens of times, but these recommendations, despite the “captain obviousness,” are followed by very few.

How to treat fatigue?

Go to the doctor and ask for “remedies for vigor” makes sense only if all of the following activities, carried out systematically, have not led to the desired result. Here they are:

1. Following a daily regimen, with the allocation of a full amount of time for sleep;
2. Planning things for the next day;
3. Start the day with morning exercises, contrast showers and physical exercises that help you empty your bowels in the morning “as planned” and make them accustomed to regular defecation. Such detoxification is very important for your health;
4. Walk or ride a bicycle to and from work, of course, if the air is not too polluted;
5. in the process of work you must not forget to switch yourself from mental work to physical work, doing the so-called industrial gymnastics. If you stand at the machine – do not forget about unloading, prevention of varicose veins;
6. It is desirable to give up bad habits, the endless “smoking breaks”;
7. It is necessary to refuse snacks and fast food at work, the consumption of coffee, it is better to take healthy food from home;
8. in the evening, after work, it is recommended to take a warm, relaxing bath, maybe with aromatic oils;
9. Take enough time for your children, and do not think about work at all;
10. Communicate with animals and plants, get a hobby, play music;
11. before going to bed it is advisable to take a walk for half an hour outdoors, or ride a bicycle, and in winter on skis;
12. Finally, a night’s sleep should not be shorter than 7 hours for an adult, and it is desirable to accustom yourself to falling asleep and waking up at the same time;
13. just before going to bed you can drink a glass of clean water;
14. in the diet must be fresh greens, fruits and vegetables, fiber, unsaturated vegetable fats, fresh, clean fish, preferably sea fish;
15. sour milk products, including those enriched with eubiotics and probiotics, are a must.

This adherence to simple rules can be considered a brief encyclopedia of a healthy lifestyle, known to all and everyone, but this is how you should start treating chronic fatigue syndrome without medication.

Medicines

What can be done if following the rules of a healthy lifestyle is not enough?? Then you need to see a doctor, and he will prescribe the necessary medications. As a rule, the treatment of various types of fatigue begins with those over-the-counter medications. They refer to adaptogens, or biogenic stimulants. We will start with this group of medications. However, if these drugs are not very effective, various immunostimulants, or immunomodulators, are added to them, they make up quite a large group.

Since an almost constant component of chronic fatigue is mood changes, irritability and episodes of depression, drugs from the group of modern antidepressants and anxiolytics are prescribed in the treatment of episodes of moderate to severe severity.

Abroad, in order to activate the patient, they sometimes use drugs which are prohibited in Russia and which are based on modified amphetamine-type substances. They were described in detail enough in the article “The best drugs for sleepiness”. Therefore, for those who want to know the state of the modern market of these drugs, we refer to this article.

For each medication, the INN is given first, that is, the international nonproprietary name, and then the name of the original drug, generics, or commercial copies, if available. Also given is an approximate range of retail prices for pharmacies of all forms of ownership in the Russian Federation for November 2019.

The order in which the remedies are listed is not intended to collect any ratings, or to give the remedies any grade, and are not promotional. Their sequence is random, and is not the result of cooperation with drug manufacturers or pharmacy companies.

Top remedies for fatigue

Adaptogens

Adaptogens are over-the-counter drugs that contain various alkaloids. By and large, they can also include tea and coffee, but we will not consider them in this review, since both tea and coffee are often involved in the development of chronic fatigue as a consequence of caffeine abuse.

Adaptogens include various extracts, infusions and tinctures of such herbal raw materials as ginseng, more precisely ginseng root, Echinacea purpurea, rhodiola rosea and marigold, Chinese magnolia-vine and common rosehip. There are several complex drugs with a pronounced activating activity. It should be known that almost all adaptogens not only increase vigor, but also nonspecifically stimulate the immune system. Let’s take a look at some of them.

Doppelgerz ginseng active elixir 250ml

Popularity Rating:* 4.9

Instead of describing monocomponent formulations that contain a single ingredient, let us talk about Doppelgerz Ginseng Aktiv. It comes in bottles of 250 ml, and 100 ml of fluid contains 3.2 g of liquid ginseng extract, some vitamin B6, nicotinamide, and caffeine.

The combined action of ginseng root extract and caffeine has a restorative effect, stimulates the central nervous system, strengthens, fights insomnia and increases physical and mental performance. Caffeine is not much in the product, only 22 mg per 100 ml. The remedy should be taken twice a day, in the first half of the day – one tablespoon, that is only 30 ml per day. In this volume the caffeine content is very low, only 7.3 mg.

For comparison, a 250 ml cup of green tea contains 30 mg of caffeine, while a cup of freshly brewed coffee may contain as much as two hundred milligrams. Therefore, even in ice cream flavored chocolate caffeine is more than a daily dose of Doppelgerz Ginseng Aktiv. Therefore, this remedy has a complex effect, and is used not only in chronic fatigue syndrome, but also in recovery from infectious diseases. Doppelherz is sold at a price of 400 to 535 rubles., muja comes in a 250 ml bottle, enough for about a week of use, and is made by the German company Kweisser Pharma.

Advantages and disadvantages

The advantage can be considered a high, German quality ingredients and phytosynthetic raw materials, and to the disadvantage – a ban on the reception at high blood pressure, excessive irritability, increased risk of seizures, as well as children under 12 years of age. Also, it should not be used by pregnant and nursing women, and in the afternoon. It is not recommended for chronic alcoholism, since a daily dose – 30 ml contains 4 grams of pure ethanol, or 9-10 grams of vodka.

Purified Altai mumie

Popularity Rating:* 4.8

There are several types of mumijo in nature, and each can be considered an excellent biological stimulant with a very broad spectrum of action. The composition of mumie consists of more than 200 different organic compounds, including – and very complex composition, and therefore the exact composition of mumie still can not be deciphered. It is known that it is based on humic acids. Mumijo contains a large number of trace elements, including phosphorus, potassium, magnesium, silicon, aluminum, sodium, iron, cobalt.

Mumijo even has such rare trace elements such as bismuth and beryllium, zirconium and barium. What is mumie consists of? It is figuratively called “the tears of the mountain giants,” and is believed to be a product of inorganic origin. Others are convinced that it is caked for 1000 years before the formation of the resin excrement wasps, bees, mountain eagles and bats.

Both of these points of view have the right to life, but mumijo is recommended not only for chronic and symptomatic fatigue syndrome, but also for all those signs that we called the “small criteria”. These are inflammatory diseases of the upper respiratory tract, signs of immunodeficiency, and autoimmune pathology. Apply mumie preferably 1-2 tablets a day, dissolving them in three tablespoons of water or warm milk. In the morning, at lunchtime and in the evening take 1 tablespoon of this solution, on an empty stomach. The course of treatment is 10 days, followed by a break of 5 days, and then the course is repeated up to 4 times. Altaic purified mumijo is produced by several domestic companies, such as LLC Pharmgroup, and Fitokom. It costs mumie in pills inexpensive, from 35 to 160 rubles. For a pack of 30 tablets.

Advantages and disadvantages

The virtue of mumijo is considered a mild and delicate effect, which can eliminate the loss of strength, minimize the symptoms of fatigue and stress. But mumie may have contraindications. Usually a condition of increased bleeding, painful and profuse periods, uterine and nasal bleeding, hypertensive crises and high blood pressure. It is not recommended to prescribe it to pregnant and nursing mothers, or children under 12 years of age.

Pantohematogen

Popularity Rating:* 4.7

In folk medicine for many centuries known tonic, strengthening and empowering effect of pantocrine on the body. Pantocrine is I a special extract from cut antlers of deer, during their annual growth period, when they are not yet keratinized and filled with blood. Horns of red deer are considered the most valuable, and therefore pantocrine the best quality is produced from the horns of Siberian, or Altai red deer. Reindeer are specially bred on farms for this purpose. The cutting of the young horns is painless and does not harm the animal.

From antlers are isolated alcoholic-water extract, and in order to get the liquid pantohematogen, you need to dilute dry pantohematogen not capable of long-term storage in ethyl alcohol, and add to it ascorbic acid and sugar syrup, as well as water. Therefore, we can consider liquid pantohematogen about the same as reconstituted milk from dried milk. In fact, the liquid extract extract extracted from the antlers directly from the Altai farms does not go on sale, but is exported.

Pantohematogen helps to improve the immune system in general, and is one of the most powerful adaptogens, surpassing in power even ginseng. It improves hematopoiesis, increases potency, gives vigor, fights against cerebration syndrome, contributes to the successful fight against adverse environmental factors, and especially at high physical and mental stress.

Apply pantohematogen should be one tablespoon, that is 15 ml 2 to 3 times a day, and preferably the evening reception is not too late. The course of reception lasts from 10 to 20 days. It is possible to take tonic baths with liquid pantohematogen. Produce the drug Pantohematogen liquid solution in 250 ml by the same manufacturers, ie Farmgroup and Fitokom. Costs a solution relatively inexpensive, from 120 to 400 rubles., This is one of the highest disparities in retail prices on the pharmaceutical market. Also produces pantohematogen Narine LLC, Biostimul, Altai Bouquet.

Advantages and disadvantages

Since pantohematogen is a very strong tonic, it is contraindicated in convulsions, epilepsy and episyndrome, with hyperfunction of the thyroid gland, with a high level of its hormones, in the presence of clinical manifestations of thyrotoxicosis. It is also undesirable for patients with agitation, excessive irritability, insomnia and high blood pressure. It is not indicated in patients with a tendency to thrombosis, with signs of heart failure, marked atherosclerosis, pregnant and lactating women.

Immunostimulants

Recall that the leading theory of the origin of chronic fatigue syndrome is still a viral aggression, which leads to immunodeficiency. Therefore, the second group of drugs that have been successfully used are stimulants of immunity. It is known that the body’s defenses are divided into cellular immunity and humoral immunity, which is realized not through the activity of white blood cells and macrophages, but through antibodies. They are produced by plasma cells, descendants of B-lymphocytes. In the fight against chronic fatigue syndrome, inexpensive and quite effective immune stimulants are used. Let’s look at some of them.

Methyluracil

Popularity Rating:* 4.9

Methyluracil are tablets with a hard-to-pronounce chemical name that have a number of unique properties. Methyluracil is a stimulant for the growth and maturation of white blood cells, or white blood cells, which protect the body from germs. It is a tissue stimulating regenerator, a mild anabolic, a drug that has the ability to strengthen the immune system and inhibit inflammation. The principle of action of Methyluracil is to activate the exchange of nucleic acids, which leads to an acceleration of the synthesis of quality hereditary material, and it is needed primarily for the synthesis of rapidly dividing cells containing nuclei.

Therefore, this medication is primarily indicated for immune cell disorders, such as low plasma leukocyte counts, or various types of leukopenia. The remedy works better in complex therapy for chronic fatigue syndrome, which is actually diagnosed, with the presence of laboratory evidence (immunogram), and there is suspicion of the viral nature of the pathology. This remedy is also used for sore throats with low white blood cell count, after treatment with X-rays, when recovering from radiation sickness, in the presence of wounds, burns and fractures. This medicine should be used as an adult 1 tablet (500 mg) 4 times a day, but no more than 6 tablets daily. A course of treatment usually lasts about a month.

Tableted Metiluracil is produced by the domestic association Biochemik, and tablets weighing 500 mg number 50 for internal use will cost from 102 to 150 rubles. In addition, Methyluracil is available in rectal suppositories, as well as in the form of ointment for external use, these two forms are even lower in price, cheaper than 100 rubles.

Advantages and disadvantages

The advantage of Methyluracil is that this drug has a complex effect on cellular immunity, and at the same time it is well tolerated. The maximum that can be after taking it is allergic manifestations, headache and mild dizziness. However, its effects on the fetus and on the body of the pregnant and nursing mother have not been investigated, so it should not be used by pregnant and nursing women. It is also contraindicated in children under the age of three. At the same time, there are serious, absolute contraindications: various malignant tumors of the blood – leukemia, myeloleukosis, lymphogranulematosis, and other conditions. In the case of leukemia, on the contrary, it is necessary not to stimulate the red bone marrow, but to suppress it so that it does not produce malignant blast cells.

Tymalin

Popularity Rating:* 4.8

Tymalin is the only drug among those presented in this review, which is not available in pills, but as a lyophilizate for the preparation of a solution for intramuscular injection, that is, Tymalin is a means for intramuscular injections, or for injections. One pack of 10 ampoules, dosage of 10 mg, will cost from 390 to 650 rubles. It is produced by a domestic company from St. Petersburg – Samson-med LLC.

What Timalin is for and how it is made? It is an extract of the thymus, or thymus gland, and is isolated from the corresponding glands of calves, and young cattle. Timalin restores the normal ratio between the different lymphocyte subpopulations, between T and B cells, promotes phagocytosis, and, like Methyluracil, improves hematopoiesis and stimulates regeneration processes.

The indication for the prescription of injections will be various immunodeficiency conditions, both in adults and children. It is known that in chronic fatigue syndrome, there is an increase in lymph nodes and symptoms of immunodeficiency, but they need to be confirmed laboratory, by special immunological studies, by immunogram. Timalin helps to eliminate immunodeficiencies and various infections, cure septic wounds, it is needed after treatment with cytostatics and immunosuppressors, and so on.

Appoint it in immunodeficiencies intramuscularly, adults 10-20 mg, that is, the contents of 1-2 ampoules, for 5-10 days. The second course, if necessary, is carried out not more often than in a month. It is also used for prophylaxis, for example, in the case of prescription of a course of chemotherapy and radiation therapy, and then we are talking about one ampoule daily intramuscularly, that is 10 mg for 5 days.

Advantages and disadvantages

Perhaps the disadvantage of Timalin is the intramuscular method of administration, this gives it the halo of a “hospital” drug. The second, and most important disadvantage is that it is a product of animal origin. And it means that in the modern, high-tech world, which switches to recombinant, genetically engineered systems of artificial production of essential substances, such as monoclonal antibodies, all extracts, extracts from animal tissues are considered “yesterday’s day” with little evidence base.

Therefore, all sales and all production of them are gradually moving to third world countries, including the Russian Federation. These drugs, which are not in demand in the West, include Actovegin from calf blood, Cortexin from pig brain, Cerebrolysin, and so on. Timalin falls into the same group. However, despite the lack of serious randomized trials, Timalin still has results, and it does help patients with a low degree of immunodeficiency to normalize their condition. And this is very important, including chronic fatigue syndrome. Contraindications for this drug are few, and, except for pregnancy and the period of breastfeeding, it is probably only individual intolerance.

Sodium nucleinate

Popularity Rating:* 4.8

Sodium nucleinate is probably the most expensive over-the-counter medication for chronic fatigue: 250 mg tablets number 50 will cost from 1,385 rubles. up to 2,150 rubles. Produces it domestic pharmaceutical company Biosintez.

Sodium nucleinate is derived from baker’s yeast and is classified by ATX as a detoxifying medicine for anti-tumor therapy with a marked immunomodulatory effect. The drug improves the leukocytic response, leukocyte production in the red bone marrow, and improves nucleic acid metabolism. It also regulates the normal proportions between the subspecies of T-lymphocytes, their cooperation with B-lymphocytes and the formation of plasma cells, improves phagocytic activity in the different pools of tissue macrophages. Thus, sodium nucleinate kind of combines the properties of both Methyluracil and Timalin. Therefore, it can be prescribed in cases of pronounced fatigue accompanied by immunologically proven deficiency, including inflammatory diseases of the upper respiratory tract, pharyngitis and sinusitis, infections such as tuberculosis, as well as for increasing the activity of vaccines, which have low immunogenicity. It is indicated in chronic alcoholism, occupational intoxications, and even senility with physical decrepitude. Of course, sodium nucleinate is not a drug for rejuvenation, but still it improves the immune system in older age.

The remedy should be used after a meal, one tablet contains 250 mg of sodium nucleinate, the daily dose of 4 to 8 tablets divided into 4 doses. The course, on average, lasts 1.5 months, and for the purpose of prevention it is used twice a year: in spring and in autumn 4 tablets a day for 3 weeks, together with multivitamins.

Advantages and disadvantages

Perhaps the most significant disadvantage is the price of sodium nucleinate, which for a month’s course will cost an average of about 5000 rubles. per month. However, compared to today’s expensive drugs for the treatment of immunodeficiencies, which are sold for tens and some for hundreds of thousands of rubles, this price can be considered very small indeed. The drug is tolerated very well, with only rare side effects such as allergic reactions. Interaction with other drugs in this drug is not identified, and it is contraindicated only in pregnant women, in the presence of hypersensitivity and during lactation.

Instead of a conclusion

It may be surprising that the list of drugs for fatigue is so quickly completed: adaptogens and immunomodulators. Of course, you can also list nootropic drugs that are used to correct attention deficits and improve memory, to optimize brain metabolism.

They are nootropics with an activating effect, such as Phenibut, the synthetic peptide nootropic Semax, and even the usual Glycine, which normalizes inhibitory processes. But about these drugs from the group of nootropics has already been written repeatedly in the relevant articles, for example, about drugs that improve memory.

Medications – antidepressants, ranging from tricyclic to serotonin reuptake inhibitors (SSRIs) are also prescribed by psychiatrists after appropriate consultations, if they find signs of depression or anxiety disorder in patients with chronic fatigue syndrome. These drugs are Azafen and Sertraline, Prozac and Fluoxetine, Stimuloton and Zoloft.

All of these drugs are already prescription, and any antidepressants are symptomatic therapy: they relieve the symptom, but do not address the cause of chronic fatigue syndrome. These remedies, too, have already been described in related articles on anxiety and depression.

Finally, as a means of symptomatic therapy in the complex treatment of chronic fatigue syndrome anxiolytics or tranquilizers are used. These are also prescription drugs, the goals and objectives of which are to reduce the severity of fear, anxiety, reduce emotional stress. These are, for example, long-known drugs such as Mebicar, Atarax, Mesapam and others. They are also already written about in the drug reviews.

However, it is extremely important for patients in whom long-term fatigue and lack of energy is the main symptom, to exclude the fast-moving malignant processes. Keep in mind that you will not be diagnosed with chronic fatigue syndrome in Russian clinics, and the doctor for such a “wasteful and costly” diagnosis will “work” on the meeting. The fact is that this diagnosis is highly refined: that is, in order to get it, doctors need to do a lot of research, exclude everything else. No medico-economic standard would allow your doctor to perform immunology tests, take bacteriological cultures and smears, perform CT and MRI scans, use other types of tests as part of a single diagnosis, such as PCRs for Epstein-Barr virus and CMV, because they would be too expensive.

In addition, the health of Russian patients is not very good even without chronic fatigue syndrome, and in most cases the cause is either cancer, or diabetes, or severe cardiovascular disease, or alcoholism with tuberculosis and drug addiction. These are the diseases that kill working-age Russians, along with trauma.

*The popularity ranking is based on an analysis of wordstat demand data..