We compare drugs Captopril and Anaprilin | Determine the best

Peak high blood pressure needs to be controlled with strong, fast-acting medications. This group of hypotensive drugs includes Captopril and Anaprilin. After taking these drugs together with diuretics, antiarrhythmic, sedatives, the hypertensive crisis is stopped. Diastolic and systolic pressures reach normal indices of 120/80 or 130/90 mm.rt.st. Depending on age indicators. People who are older do well with a blood pressure of 130/90 mm.rt.st., So you have to be extremely careful when cupping a crises, low readings can lead to fainting. Journalists of the publication “Expertology” have studied in detail interesting facts: what is better “Captopril” or “Anaprilin” and how they differ, and are ready to share them with the general public.

Captopril

The drug is part of a group of natural and chemical compounds used in cardiology and nephrology. Captopril or Capoten, has high efficacy in the treatment and prevention of cardiac renal failure, and also has a regenerating effect on wounds after plastic surgery, it is a protection against ionizing radiation. Hypotensive, thanks to its fast-acting property, is widely used in cardiology to relieve hypertension of different genesis. The drug contains the active ingredient captopril plus additional substances magnesium stearate, starch, lactose monohydrate, talc. Available in 25mg, 40mg, and 50mg doses.

Mechanism of action

Captopril inhibits the effects of angiotensin-converting enzyme category one, and angiotensin category two. The latter relieves vascular spasm, increases aldosterone production in the adrenal glands. The second action, is a decrease in the kinin-callicrein system and suppression of bradykinin breakdown. Both reactions have a hypotensive effect, leading to normal readings, both systolic and diastolic parameters. By reducing the concentration of renin in the blood, the drug restores coronary and renal blood flow, providing a normal amount of oxygen to these organs, as well as preventing tissue ischemia. Captopril is completely soluble and adsorbed in the stomach, circulating in the blood as metabolites. Reaches high concentrations after 1.2 to 2 hours after ingestion. Completely eliminated by the kidneys.

Important facts from Expertology magazine! The modern WHO classification divides BP according to the level of its increase into three degrees:

1. Grade I: BP 140/90-160/99mm.rt.st.;

2. Grade II: 160/100-180/110mm.Hg.stenocardia.;

3. Grade III: 185/110mm.rt.st. and more.

As a result of positive treatment of hypertension, frequent self-monitoring of blood pressure. Frequency of measurement should be performed in the morning, at noon, at lunchtime, and in the evening before going to bed. According to these results, the therapeutic dose of Captopril can be individually selected.

Taking Captopril: indications and contraindications

Hypotensive mainly reduces blood pressure, eliminates vasospasm and improves kidney function. But, its active ingredient can not only lower blood pressure, and relieve spasms of veins and arteries, eliminating brain strokes, as well as improving blood flow of the kidneys “saving” them from sclerosis.

Captopril is recommended for:

1. Hypertension of any genesis;

2. coronary disease;

3. Postinfarction period;

4. cardiac insufficiency;

5. combined cardiac pathology (ischemia, mitral insufficiency), diabetes mellitus, nephropathy;

6. angina pectoris;

7. hypertension of endocrine origin;

8. vascular disease;

9. kidney disease.

Heart failure is treated with a whole complex of drugs, the main one is Captopril. During 3-5 days, the dose is equal to ¼ tablet, taking it 3 times a day, then 5 days it is taken 0.5 tablet twice a day, and then it is possible to take 1 tablet in the morning and in the evening with constant pressure measurement. According to the same scheme, postinfarction state is treated. Diabetic nephropathy requires up to 100ml per day, that is, 2 tablets. The side effects of the drug require cancellation, so after familiarizing yourself with the topic: What is better “Captopril” or “Anaprilin” and how they differ, you can take the second drug, but only after consulting with your doctor.

List of contraindications:

1. allergy;

2. Bronchial asthma and respiratory insufficiency;

3. cachexia;

4. Pregnancy and lactation;

5. Urolithiasis and impaired kidney function;

6. cirrhosis;

7. hyperkalemia;

8. cancer.

Hypotensive is included in the treatment of post-stroke, vascular, and renal pathologies. The entire course of therapy is under constant medical supervision to rule out unforeseen reactions. Elderly patients are selected an individual dose depending on the accompanying chronic pathologies. In such cases, you need to be aware of what is better “Captopril” or “Anaprilin” and how they differ, choose a gentle + effective drug.

It is proved by our employees that captopril is contraindicated for pregnant women because of the disturbance of pregnancy. It causes intrauterine fetal growth abnormalities such as skull underdevelopment, renal failure, hypertension. During lactation, the drug enters the baby’s body, causing diarrhea, nausea, lethargy, allergies, and fainting.

The body’s responsiveness to captopril

Taking a drug to normalize BP causes many side effects. Prescribe, this drug, should be prescribed with caution and only after collecting the anamnesis and obtaining the results of laboratory and instrumental examination.

Undesirable reactions:

1. Increased allergic background: rash, spots or Quincke’s edema, specific cough, bronchospasm;

2. Gastrointestinal reactions: bleeding gums, nausea, vomiting, diarrhea, dryness and bitterness in the mouth, cirrhotic changes in the liver, gastric and duodenal ulcers;

3. Cardiovascular system disorders: tachycardia, arrhythmia, severe heart pain, feeling of cardiac arrest;

4. CNS: migraines, insomnia, inadequate movements, decreased vision, fainting,

5. Kidneys: increased levels of urea, nitrogen, potassium, and Ca in the blood and urine.

If one of the above reactions occurs, the drug is discontinued. Another hypotensive agent is selected according to the indications. Overdose is manifested by hypotension, drowsiness, dizziness, confusion. Self-treatment is strictly prohibited, otherwise life will be in danger and the ambulance will not be able to help, even if it comes early!

Anapriline

Hypotensive drug from the group of peripheral β-blockers₂-of adrenoreceptors . The active ingredient is propranolol (prorganolol). Non-selective inhibitor, has triple effect: antihypertensive, antianginal and antiarrhythmic. Reduces the pressure, regulating it to the limit of normal values, relieves vasospasm of the central and peripheral type, and regulates the heart rhythm. Taking the drug reduces tremor by blocking β₂-Adrenoreceptors, relieves arrhythmias and improves heart muscle function. Widely used in cardiology to treat cardiovascular disease. Employees of “Expertology” magazine will help to dispel doubts about the effectiveness of the drug, giving a comparative analysis of the drugs and covering all about: What is better “Captopril” or “Anaprilin” and how they differ.

Pharmacological action

The effect of the drug, namely the active ingredient propranolol, is to inhibit β-adrenoreceptors. Decrease in catecholamines, no synthesis of CAMF from adentrophosphoric acid, resulting in reduced Ca ion penetration into cells. Decreased rate of spontaneous excitation of the sinus and ectopic conduction of the heart rhythm and slower AV conduction. This reaction leads to elimination of arrhythmia + tachycardia. Hypotensive effect occurs after the reduction of blood, inhibition of the renin-angiotensin complex + sympathetic effects on the vasculature. Through this mechanism, the heart rate is normalized.

Total peripheral vascular resistance increases, the entire system tries to return the former α-adrenoreceptor function, after a day everything subsides. And after 5-7-14 days of taking Anaprilin, blood pressure begins to normalize, BP spikes will not be observed. The pills dissolve completely and are absorbed in the stomach and intestines. Binds to proteins in the blood as metabolite. Maximum concentration occurs after an hour or 1.5 hours. It is eliminated from the body by the kidneys.

Important! Anapriline, is a class II antiarrhythmic drug. It dilates blood vessels, providing the necessary amount of oxygen and nutrients to the heart muscle, plus it corrects the heart rhythm, eliminating arrhythmia. Complete course of treatment therapy stabilizes heart function.

Recommendations for use

The main indication is high blood pressure. The drug decreases high systolic and diastolic blood pressure values for 15-20 minutes. Tremors decrease and migraines go away.

List of Recommendations:

1. Angina pectoris (rest and tension).

2. Spiking angina pectoris.

3. Tachycardia (sinus, supraventricular and ventricular).

4. Atrial fibrillation.

5. Alcohol dependence.

6. Thyrotoxicosis with hypertension.

7. CNS disorders.

Anapriline is indicated for hemangiomas; it increases blood supply and tissue nutrition. Plus inhibits Ca ion penetration and eliminates ischemic process. In this pathology, a stronger drug like Captopril can be used.

Dosage form

In adults it is recommended orally 20 mg/2-3 times a day. The maximum dose is up to 320 mg/day. Intravenous dose varies from 3 mg to 10 mg. Administered via a drip, slowly. Blood pressure and electrocardiogram should be monitored at all times.

Side effect

Unexpected reactions after taking Anaprilin result from intolerance to the drug and the complexity of the diagnosis accompanied by chronic disease.

Reactions to hypotensive drug:

1. Reactive processes: allergic rash, spots, anaphylactic shock, Quincke’s edema, specific cough, bronchospasm.

2. Gastrointestinal reactions: bleeding gums, nausea, vomiting, diarrhea, dryness and bitterness in the mouth, cystic changes in the liver, worsening cholecystitis, gastric and duodenal ulcers, increased activity of liver transaminases, LDH.

3. Cardiovascular system reactions: bradycardia, hypotension, arrhythmia, AV blockade, feeling of cardiac arrest plus chest pain, coldness in the lower extremities, Raynaud’s syndrome.

4. CNS: increased fatigue, weakness, dizziness, headache, drowsiness or insomnia, nightmares, depression, anxiety, confusion, hallucinations, tremors, nervousness, restlessness.

5. Kidneys: increased levels of urea, nitrogen, potassium and Ca in the blood and urine.

6. Endocrine system: increase in sugar indexes.

7. Skin: hot flashes, psoriatic spots, dermatitis.

In blood tests, there is a decrease in platelets and leukocytes, as well as anemia. Due to vascular spasms, the blood circulation of the lower extremities is impaired, there is a feeling of numbness and icing. Plus to the above, join such reactions as seizures and fainting.

Contraindications to use

Hypersensitivity to propranolol, AV-blockade, bradycardia, hypotension, decompensated heart failure, cardiogenic shock, cirrhosis of the liver, and pulmonary edema, vein and artery disease, angina pectoris, late-stage diabetes, and renal failure are direct contraindications for taking Anaprilin. With such a list, it is worth reconsidering: What is better “Captopril” or “Anaprilin” and how they differ, and change the hypotensive agent for a more gentle.

Important! Hypotensive drug is incompatible with many medications, so it must be used with caution!

Hypotensive drugs Captopril and Anaprilin: similarities and differences

Prescribed above hypertensive drugs Captopril and Anaprilin, selectively act to reduce blood pressure by relieving vasospasm, improving blood flow, increasing oxygenation of heart tissue and regulating the heart rhythm.

These drugs have some similarities and differences, namely:

Hypotensive drugs, are strong cardiac medications. Both are widely used in the treatment of high blood pressure of any genesis, as well as renal failure and even endocrine disease. The only difference is the composition of the active substance and the mechanism of action.

Conclusions

Hypertension is one of the medical and social problems of the Russian Federation plus the whole world. In our country statistically about 20% of young people and 60% of adults suffer from the disease. Year after year, the number of patients is increasing; along with this number is the risk of complications of this genesis, namely myocardial infarction, angina pectoris, atrial fibrillation, and stroke of the brain. This list leads to serious consequences in systems and organs, as well as death. In the exclusion of such a finish, it is necessary to consult a doctor in time, take appropriate measures in a timely manner and engage in effective treatment. And the information: What is better “Captopril” or “Anaprilin” and how they differ, will help in choosing the right treatment option.