Comparing Pangrol and Pancreatin | Determining the best one

Digestive problems require a comprehensive treatment approach. And drugs like Pangrol and Pancreatitis are good for this. These are enzyme agents, the action of which is similar in many ways, but there are important differences. We have broken down their advantages and disadvantages to find out which drug is best to choose for different gastrointestinal disorders.

Digestive problems




Convenient dosage

May cause diarrhea

Well tolerated

Not suitable if intolerant to porcine pancreatin

No serious contraindications

Used in childhood

May be prescribed for lactation

Large list of indications




More often used in long-term therapy due to low cost

Smaller amount of the active ingredient

Fewer side effects

May cause allergies

Often used in preparation for abdominal examinations

Prolonged use may cause hyperuricemia

Pangrol product description


The enzyme drug Pangrol is available in enteric-soluble capsules. It contains pancreatic enzymes (hereinafter referred to as PGE) – lipase, amylase, protease. Produced by Ber

  • n-Chemie AG . The main purpose of the drug is to make up for enzyme deficiencies.

    The active ingredient is porcine GI powder. The enzymes that it contains help to break down proteins, fats, carbohydrates. Additional intake of pancreatin is necessary for humans with various diseases and special diets that require limiting the intake of certain substances. Enzymes allow you to diversify your diet without harming your health.

    Pangrol has a positive effect on digestion, normalizing absorption and assimilation of nutrients. Its use improves gastrointestinal function and compensates for pancreatic insufficiency.

    Study and efficacy

    Administration of Pangrol in patients with functional dyspepsia caused by dysfunction of DU contributes to relief and complete disappearance of pain syndrome. Treatment of children yields positive results in the form of improved laboratory values.

    Pangrol is available in a convenient dosage form that allows you to accurately calculate the right dose by weight. The drug is well tolerated and causes no side symptoms, so it can be recommended for the treatment of children with failing gut with functional dyspepsia.

    Pangrol is successfully used as replacement therapy for cystic fibrosis. The enzyme medication is usually taken after each meal, so good tolerability of the medication is extremely important, which is characteristic of Pangrol.


    1. “Pangrol in the correction of pancreatic insufficiency in children with functional dyspepsia”. Belousova O.ju. 2013.

    2. “Efficacy and safety of the mini-tablet pancreatin Pangrol in patients with cystic fibrosis.”. Orlov A.v. 2016.


    Contraindications to taking Pangrol are such conditions:

    1. exacerbation of pancreatitis;

    2. Hypersensitivity to the composition;

    3. acute pancreatitis.

    There is no information on the use of PJ medications in pregnancy. No negative effects have been found in animal studies. Toxic effects on the fetus and effects on reproductive function when taking Pangrol are not expected. The doctor may decide to prescribe the drug when the benefit exceeds the risk.

    Can be taken while breastfeeding. Pangrol has no ill effects on the baby through breast milk, which is also known through animal studies.

    Side effects

    Pangrol is well tolerated. Adverse reactions are rare. Possible unpleasant symptoms include bloating, nausea, diarrhea and vomiting. These are the most likely. Their very rare – rash, urticaria, abdominal pain.


    The dosage is adjusted individually by weight. If there are no other indications, it is taken in 2-4 capsules with a dose of 10000 IU with each meal. It is not recommended to exceed the dose of 15000-20000 IU per day.

    Overdose may be accompanied by hyperuricemia and hyperuricosuria. In this case, the medicine is discontinued. Requires symptomatic treatment under medical supervision.

    Who is suitable

    Pangrol has the following indications for use:

    1. Pancreatitis with a chronic course;

    2. cystic fibrosis;

    3. Subacute pancreatitis;

    4. Gallstones and tumors narrowing the duct of the RV;

    5. After resection of the RV;

    6. functional disorders of the gastrointestinal tract;

    7. Consumption of food that is difficult to digest.

    Pancreatin drug description


    Pancreatin is an enzyme with proteolytic, lipolytic and amylolytic activity. Available in the form of pills. Manufacturers in Russia are Biosintez, Pharmproject, Avexima, Irbit Khimpharmzavod.

    The drug replenishes the lack of GI enzymes, improves digestion, promotes the breakdown of proteins, accelerating their absorption, activates the small intestine.


    Pancreatin is contraindicated if the components are intolerant, with acute pancreatitis and its exacerbation. It is not recommended to use during pregnancy.

    Side effects

    The enzyme preparation is very well tolerated. Possible side symptoms include allergies. If atypical reactions occur, it is necessary to inform the doctor.


    Taken after meals 1-3 tablets a day. For children, the dosage is selected individually. Treatment can last up to several years, when continuous replacement therapy is carried out. Short courses can last several days.

    The effectiveness of Pancreatin is reduced when combined with antacids and drugs containing magnesium hydroxide.

    Who is suitable for whom

    Pancreatin is recommended for:

    1. Impaired function of the prostate gland;

    2. Cystic fibrosis;

    3. dyspepsia syndrome;

    4. radiation;

    5. Chronic pancreatitis;

    6. Gastric and intestinal resections.

    The enzyme drug Pancreatin can also be used prophylactically for normal digestion. This is recommended when eating disorders, eating fatty foods.



    The remedy




    10000 №50 – from 590 rubles

    10000 #20 – from 270 rubles










    125 mg #50 – from 60 rubles

    23 units #60 – from 50 rubles

    Which drug is better

    Pangrol differs in that it is produced by foreign companies, have a higher price. As for the difference in terms of quality, it lies in the content of more of the active ingredient. Pancreatin is a domestic drug, an analogue of a foreign drug. It is more often preferred, since usually a prolonged therapy is needed, when the cost is important and minor differences are not taken into account.

    Pangrol is used in pediatrics and, if necessary, is prescribed for pregnant women. Pancreatin is preferred when lifelong supportive therapy is needed.

    The drug should be selected by a doctor who prescribes tests and conducts examinations. The effectiveness of the enzyme depends largely on the right choice of dosage and the frequency of intake. Self-treatment can be dangerous.

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