Comparing Monural and Furadonin | Determining the Best

Monural and Furadonin are commonly prescribed antibacterial drugs for cystitis. Their antimicrobial action can fight many other diseases. We have studied the features of these drugs to conclude which one is better.

Description of Monural

Antibacterial drug with bactericidal action Monural is available in granules for the preparation of a solution taken orally. Its main active component – phosphomycin. Produced in Switzerland by Zambon Switzerland. Recommended for the treatment of urinary tract infections.

Research and efficacy

The drug Monural can be considered the most effective and safe in the treatment of uncomplicated urinary tract infections. It is successfully used for cystitis and pyelonephritis, whereas resistance to other agents develops very quickly.

The lowest resistance of uropathogenic bacteria to phosphomycin has been established. In a comparative analysis, an important advantage of a drug based on it is found. A single application of 3 g of Monural is equal in therapeutic effect to a week’s use of norfloxacin. Eradication of the infectious agent was 98% and 96% respectively, indicating the high effectiveness of phosphomycin in Monural.

Since 2002, Monural belongs to category B, that is, it is recommended in the treatment of bacteriuria, cystitis in pregnant women and adolescents, which is due to its low toxicity and pharmacokinetic parameters.

Source: “Prospects for the use of Monural in gynecological and urological practice”. Babuk I.a. 2010.

Contraindications

Monural is contraindicated for hypersensitivity to the active substance. It is prohibited in kidney failure and under the age of 5 years.

In pregnancy is prescribed with caution when the benefit exceeds the risk.

Side effects

Monural is well tolerated. Rarely causes a skin rash. There is a possibility of occurrence of disorders of the digestive tract – diarrhea, nausea, heartburn. Dyspeptic symptoms go away on their own after excretion.

Dosage

It is taken before or after a meal. The pellets are dissolved in 1/3 cup of water. One sachet – 3 g is used. Children take 2 g. It is taken as a single dose; the course of treatment is 1 day.

Who is suitable

Monural is indicated when:

1. Bacterial cystitis;

2. pyelonephritis;

3. Asymptomatic course of bacteriuria;

4. Urethritis.

Monural may be administered as a prophylactic agent when there is a risk of infectious lesions after surgery and diagnostic manipulations.

Description of Furadonin

Furadonin is an antimicrobial drug based on nitrofurantoin. It is used for the treatment of infectious and inflammatory pathologies of the urinary tract. Active against bacteria causing urogenital infections. Available in tablets and suspension by the companies Olainfarm and Borisovsky ZMP.

Research and efficacy

Nitrofurantoin is used to treat uncomplicated cystitis in women with a 7-day course. This therapy gradually replaces a 3-day course of treatment with trimoxazole due to the development of resistance to it. Nitrofurantoin preparations can be considered as an effective and safe alternative for the treatment of cystitis.

Active against streptococci, enterobacteria, staphylococci, salmonella, shigella and other bacteria, causative agents of urinary tract infections. It is used for cystitis and long-term therapy of pyelonephritis.

Furadonin has proven to be a well tolerated drug in clinical trials. In rare cases, it causes dyspeptic symptoms. It is the best known nitrofuran drug for the treatment of urinary tract infections. This limits its scope of application, since the concentration of the substance is observed only in the urine.

Sources:

1. Hooton T.M., Roberts P.L., Stamm W.E. Short-Course Nitrofurantoin for the

   Acute Uncomp
2. Cystitis in Women. 2007.

3. Nitrofurans in the pharmacotherapy of urinary tract infections. Vdovichenko V.p. 2012.

Contraindications

Furadonin is contraindicated in chronic renal failure, hypersensitivity to the compound, heart failure, hepatitis, cirrhosis, porphyria.

The drug is not used in the first month of life, during lactation and pregnancy. With caution is prescribed for diabetes, anemia, hypovitaminosis B.

Side effects

Side effects are more likely to occur with prolonged use of the medication. It may be dyspeptic manifestations, drowsiness, fever, bronchoobstructive syndrome. Also the risk of nystagmus, pancreatitis, hepatitis, cholestatic syndrome is not excluded. Some patients note painful sensations in the abdomen.

Dosage

Adults take 100-150 mg 3-4 times a day, up to a maximum of 600 mg per day. The course of treatment lasts up to 10 days. Prescribed at 5-8 mg/kg/day in children.

Vomiting occurs in case of overdose. It is indicated to drink a lot of water.

Who is suitable

Furadonin is successfully used to treat diseases such as:

1. pyelonephritis;

2. Cystitis;

3. Urethritis;

4. pyelitis.

Cost and analogues

Which drug is better

Monural is effective for relieving acute symptoms of cystitis, urethritis, bacteriuria. It is also good as a prophylactic after surgery.

Furadonin is used for long-term treatment of cystitis and pyelonephritis. The tablets are used before diagnostic procedures to prevent complications.

Monural is more convenient to take. This drug has fewer contraindications and less risk of adverse reactions. It is also allowed in pregnancy. In pediatrics, the drug Furadonin is preferred. Can be taken from as early as the second month of life.

It is the doctor who chooses the drug after identifying the infection and its causative agent. Self-treatment is not allowed. Antibacterial drugs can lead to side effects.