Both thrombo-ACS and Courantil are prescribed for the prevention of blood clots in cases of high blood viscosity. Their mechanism of action is similar, but the active ingredients are different. Therefore, we have parsed and compared both remedies to determine which one is better.
Stronger blood thinning effect;
Prolonged treatment may cause peptic ulcer and gastric erosion;
Some studies question efficacy.
Less risk of adverse reactions;
Can be prescribed for pregnant women;
Permitted from the age of 12 years;
Effective in the prevention of SARS.
During the course, you should avoid foods and drinks with caffeine;
Description of Trombo ACC
Thrombo ACC refers to anti-aggregant, that is, blood thinning agents. It contains acetylsalicylic acid, which is an NSAID. The action is to block the synthesis of thromboxane, prostaglandins and prostacyclins. The drug reduces platelet adhesion and decreases thrombosis.
Available in 50 and 100 mg tablets. Produced in Austria by G.L.PHARMA, GmbH. Available without a doctor’s prescription.
The remedy has several actions at the same time:
Dilates blood vessels;
stops the inflammatory process;
relieves painful sensations.
The drug contains silica, cellulose, lactose monohydrate, and starch as excipients. The tablets are white in color and have a slightly rough surface.
Research and efficacy
In “Thrombo ACS in the Therapy of Cardiovascular Pathology,” Dr.m.n. Zadionchenko B.s. concluded that use of the drug prevented up to 20 heart attacks in 1,000 patients. Most recommendations involve often lifelong use of ASA. The effectiveness of the drug for the prevention of pathologies of the cardiovascular system has been proven.
The ASPREE study, which evaluated the effectiveness of acetylsalicylic acid in preventing heart disease, found that patients who took aspirin had a higher mortality rate. The study included 19,114 participants, half of whom used placebo and the other half used acetylsalicylic acid.
Nonsteroidal anti-inflammatory drugs pose the greatest risk to the gastrointestinal tract. It is not advisable to take them for a long time. Therefore, the first contraindication would be gastrointestinal pathologies in the period of exacerbation.
What other restrictions are there to the use of antiaggregant agent Thrombo ACC:
intolerance to ACS and auxiliary components;
Chronic insufficiency of heart function;
Carrying a fetus in the first and third trimester, breastfeeding;
Severe renal failure.
The drug is not prescribed before the age of 18 years. In the elderly, the drug is used, but the risk of overdose is significantly higher, so a dose adjustment may be necessary.
Trombo ACS is prescribed in a small dosage, which further ensures its safety. It is well tolerated; adverse effects are rare.
What may be the side symptoms of use:
dyspepsia, abdominal pain, ulcers, bleeding;
allergies – bronchospasm, anaphylactic shock, swollen nasal mucosa.
There are reports of severe bleeding, especially in people with high blood pressure. Hypertension increases the risk of stroke.
Thrombo ACS is taken before meals. The medication is usually prescribed for long-term use. The duration of the course depends on the doctor’s prescription.
For heart attack prevention, 50-100 mg is prescribed. The same dose is indicated for angina pectoris. To prevent thrombosis, 100-200 mg is prescribed.
Who is suitable
Trombo ACS is well-proven for primary and secondary prevention of heart attack when there are serious risk factors – persistent high blood pressure, diabetes.
In what other cases the drug Thrombo ACS may be used:
Having had a myocardial infarction to prevent a recurrent attack;
For stroke prevention;
Prevention of pulmonary embolism.
Antiaggregant agent is widely used after invasive vascular interventions. Particularly after aortocoronary bypass surgery, angioplasty, stenting.
Curantil also belongs to antiplatelet agents, but contains a different active ingredient, dipyridamole. The drug has anti-aggregation, immunomodulatory and angioprotective effects.
Available as 25 and 75 mg tablets. Produced in Germany by Berlin-Chemie AG/Menarini Group.
The tablets contain excipients such as starch, gelatin, lactose monohydrate, silicon dioxide, magnesium stearate. Available in 100-pack and 120-pack vials and 20-pack blister packs.
Studies and efficacy
In the article “The use of dipyridamole (Curantil) for the secondary prevention of stroke”, published in the Journal of Neurology and Psychiatry named after V.I. Vavilov, it is described. s.s. Korsakov, described a study in which 45 people participated, 30 of whom took Courantil 75 mg 3 times a day. The control group consisted of 15 patients who did not take the drug.
During a 6-month follow-up, no recurrent cerebral circulatory disorders were reported in the group that took Curantil. Recovery of patients during treatment with dipyridamole was more pronounced and faster. In a control group of 15 patients, 2 recurrent cerebral circulatory disorders were noted.
Curantil is not prescribed in case of hypersensitivity to the active component.
There are other limitations to prescribing the drug:
heart attack and angina pectoris;
Ulcer disease during an exacerbation;
During pregnancy, the drug may be prescribed, but only under the supervision of a physician and strictly on the basis of indications. This also applies to the period of breastfeeding.
Unwanted symptoms occur very rarely. Nausea, myalgia, tachycardia, skin allergic reactions, facial hyperemia may occur.
Curantil is taken in the morning on an empty stomach. The standard dosage is 75-225 mg in several doses. In complicated cases, the dose may be increased to 600 mg.
For prevention of acute respiratory infections and flu, 2 tablets of 25 mg once a week for a month is indicated. To prevent recurrence in frequent viral illnesses, 50 mg 2 times a day once a week for 2 months.
Who is suitable
Curantil, like Thrombo ACS, is used for cerebral bleeding disorders and to prevent thrombosis. But there are other indications for its use.
In what cases is it effective to use the drug Curantil:
Placental insufficiency when carrying a fetus;
Prevention of acute respiratory infections and influenza, as well as their therapy;
Curantil can be used in the treatment of any abnormalities in the microcirculation. As an interferon inducer, it is good for viral diseases.
Cost and analogues
Tablets 100 mg #100 – from 140 rubles;
50 mg #100 – from 125 rubles
Tablets 25 mg #120 – from 605 rubles;
75 mg #40 – from 775 rubles
What is the best drug
Thrombo ACC has a stronger blood thinning effect, while Curantil is additionally an interferon inducer. This suggests that the first drug is more often prescribed for serious circulatory disorders. However, Trombo ACC is more aggressive on the gastrointestinal tract, which can lead to ulcer disease.
When it is necessary to treat children from 12 years old, pregnant women, the elderly and people with gastrointestinal diseases, the drug Curantil is preferred.
Which drug is better, the doctor decides. To choose a safe and effective medication, you need to assess the severity of the underlying disease and take into account the general state of health. Self-treatment in this case is dangerous, you need to consult a specialist.