Buscopan and Duspatalin are used in the treatment of peptic ulcer and diseases that are accompanied by gastrointestinal spasm. These antispasmodics have a lot in common, as well as many differences. We took apart both drugs to find out which one is best and when.
Two forms of release – capsules and suppositories
More adverse reactions
Fast action – 10-15 minutes
Not used in pregnancy
Excellent for abdominal pain
Contraindicated before 6 years of age
The suppositories may replace the popular drug Noshepa, with greater safety for children
Not suitable for long-term therapy
Available only in capsules
No serious contraindications
Delays the onset of the effects
Used in pregnancy
Can be prescribed from 12 years of age
Can be used for a long time
Highly effective in the treatment of irritable bowel syndrome
Description of the drug Buscopan
The m-choline antispasmodic Buscopan is available in tablets and suppositories by Abbott Healthcare Products B.V. In the Netherlands. The action of the drug is aimed at eliminating the spasm of the musculature of the internal organs. It is used for gastric and 12 duodenal ulcer, colic.
Relaxes not only the gastrointestinal tract, but also the biliary and urinary tracts. Therefore, it is also widely used for diseases of the hepatobiliary and urinary systems.
The main active ingredient of the drug is Hyoscini butyl
omidum. Hyoscine butyl bromide can be used from age 6 to treat diseases of the digestive and excretory systems.
The active ingredient has atropine-like action. These are increased heart rate, increased intraocular pressure, dilated pupils. Significant therapeutic effects in the drug Buscopan stand out the ability of hyoscine butyl bromide to relax the muscles of the gastrointestinal tract, urinary and biliary tract, slow the motor function of the intestines, reduce the secretion of salivary glands. The drug acts mainly in the colon.
Research and effectiveness
In a study on the effectiveness of the product in chronic pancreatitis 52 patients took part. Results show that Buscopan reduces the intensity of pain within 2 weeks of use. The established optimal dosage of the drug is 20 mg of the product 3 times a day. With this regimen, the pain index was reduced by a factor of 4. The frequency of side effects has also been found to be 14%, regardless of the dosage chosen.
The drug is also used in gynecology. Antispasmodic agent in the form of rectal suppositories should be prescribed for diseases of the pelvic organs. Buscopan is effective for elimination of pain syndrome caused by smooth muscle spasm.
Potential use of hyoscine butyl bromide (Buscopan) in the treatment of patients with chronic pancreatitis. Mishurov T.s., Belousova E.a. 2009.
Experience of Buskopan antispasmodic in gynecological practice. Akarachkova E.s. 2009.
Buscopan has the following limitations to use for adults and in pediatrics:
Under 6 years of age;
Carrying a fetus, breastfeeding;
Hypersensitivity to one or more elements in the composition;
A malformation of the colon, its enlargement;
Myasthenia gravis is an autoimmune disease associated with rapid fatigue of the transverse striated muscles.
Need a preliminary risk assessment if intestinal obstruction, obstruction of the urinary tract is suspected. Prescribed with caution in diseases of the visual organs, especially in closed-angle glaucoma.
In case of pain of unclear origin, fever, blood in the feces before or during treatment, it is necessary to consult a doctor immediately, stopping the use of the drug.
There is insufficient information on the safety of Buscopan during pregnancy and lactation. Whenever possible, the drug is not prescribed to these groups of patients.
Side symptoms from taking Buscopan are related to the anticholinergic effect of the active ingredient. Undesirable manifestations are temporary, not dangerous to health and pass on their own. This does not replace the need to inform the physician of such cases. In some situations, it may be necessary to cancel the medication.
What may be the side effects during treatment with Buscopan:
immune reactions – shock, shortness of breath, skin itching, erythema, rash, urticaria;
Increased heart rate, abnormal heart rhythm;
Decreased urine output, urinary retention.
Drug interactions must be considered. Buscopan can increase the effect of antidepressants, antipsychotics, antihistamines. It is not recommended to combine with dopamine antagonists, since there is a decrease in the effectiveness of both drug groups. The use of beta-adrenergic agents increases the risk of increased tachycardia.
Buscopan is usually prescribed in short courses. From 6 years old children and adults are shown 1-2 tablets 3-5 times a day. The suppositories are used according to a similar scheme. It is prohibited to use the drug for more than 3 days without a doctor’s consultation.
No case of overdose has yet been described. Symptomatology in case of significant overdose will be related to the pharmacological effects of the active ingredient. Anticholinergic effects such as urinary retention, skin hyperemia, visual disturbances, inhibition of GI motor function, and tachycardia are possible.
To treat the symptoms of overdose, symptomatic drugs will be used, depending on the violations that have occurred. The symptoms are treated with cholinomimetics. Glaucoma will require the use of pilocarpine eye drops. Cholinomimetics, such as intramuscular or intravenous neostigmine, may be administered. In case of cardiovascular complications, treatment is carried out according to standard therapeutic recommendations. Catheterization is indicated for urinary retention.
Who is suitable
The drug Buscopan, according to the instructions, is suitable for the following conditions and diseases:
Renal, intestinal and biliary colic;
Biliary tract and gallbladder dyskinesia associated with spasm;
Peptic ulcer disease of the stomach and 12 duodenum;
Description of the drug Duspatalin
The myotropic antispasmodic Duspatolin is available in 200 mg tablets from Abbott Healthcare Products B.V. The active ingredient of the drug is mebeverine. The drug directly affects the smooth muscles of the gastrointestinal tract, especially the walls of the large intestine. It does not affect peristalsis and has no anticholinergic effect.
The drug is used from 12 years in pediatrics and for adults for the treatment of functional disorders of the digestive tract and excretory system.
There is no strong cumulation when the drug is taken for a long time and repeatedly. The tablets of mebeverine are characterized by a prolonged release. The drug is excreted by the kidneys and with the bile.
Research and efficacy
Duspataline is the drug of choice for functional gastrointestinal disorders. It is widely used as a symptomatic agent for abdominal pain caused by spasm.
The drug’s safety data came from a study of more than 3,500 patients. Mebeverine is well tolerated, even when using doses that are higher than recommended. Most patients note the complete absence of any side effects during treatment with Duspatalin.
An important advantage of the drug is its selective action. Smooth muscle contractions are not completely suppressed and intestinal peristalsis is not inhibited. Mebeverine has two main therapeutic effects. It has an antispastic effect but reduces potassium outflow without causing hypotension.
The drug Duspatalin is effective in relieving symptoms caused by impaired bowel and biliary tract motility. It may be included in complex therapy of functional disorders of gastrointestinal tract, which are accompanied by pain, cramps, stool consistency changes, defecation frequency disturbances.
Source: Duspataline in the treatment of functional bowel and biliary tract diseases. Klimov A.e. 2003.
The only serious contraindication to the prescription of mebeverine is its intolerance. No teratogenic effects have been found in animal experiments. The drug may be prescribed during fetal delivery when the benefits outweigh the risks. The substance does not penetrate into breast milk and can therefore be used during lactation.
Very rare unwanted effects of using Duspataline are dizziness, urticaria, allergies, exanthema and facial edema.
Duspataline is taken 200 mg 2 times a day half an hour before meals. It is recommended to drink capsules in the morning and evening, without chewing, not breaking, drinking clean water.
An increase in the recommended dosage may cause increased CNS excitability. No such cases have yet been reported. Treatment will require gastric lavage, consult a physician for selection of symptomatic medications.
Caution should be exercised when driving vehicles and complex mechanisms, when increased concentration and high speed of psychomotor reactions are required.
Who is suitable
Duspatalin is prescribed for the following diseases:
Gastrointestinal spasm on the background of organic diseases;
Abdominal pain associated with functional disorders;
Irritable bowel syndrome;
Biliary and intestinal colic.
Cost and analogues
Tablets 10 mg #20 – from 340 rubles
Suppositories 10 mg #10 – from 380 rubles
In tablets and solution, used for urinary tract and gastrointestinal spasms, to relieve nausea, as an antidote for poisoning with organophosphorus compounds
Tablets 135 mg #50 – from 610 rubles
In capsules, indicated for biliary dyskinesia, GI spasms, cholecystitis, biliary and renal colic
In capsules, prescribed for gastrointestinal spasms colic, IBS, functional disorders of the digestive organs, which are accompanied by pain
Which drug is better
Duspataline and Buscopan are myotropic antispasmodics. They are highly selective, concentrating specifically in the gastrointestinal tract. Have low toxicity and low risk of adverse reactions.
Buscopan is notable for its rapid action. The effect is noticeable in 15 minutes after taking it. The suppositories work even faster. Additionally used in gynecology.
Duspataline only affects the intestinal wall. It can be used for a longer period of time – up to 15 days, and in some cases up to 2 months.
Duspataline is best used for long-term therapy of chronic gastrointestinal diseases. Buscopan is preferred for rapid pain relief. Before using the medication, you should consult with your doctor. If adverse reactions occur, you need to stop taking the remedy and inform a specialist.